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Key Documents

RAB1515

Sigma-Aldrich

Human IL-12 R beta 2 ELISA

for serum, plasma and cell culture supernatants

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About This Item

UNSPSC-Code:
41116158
NACRES:
NA.32

Speziesreaktivität

human

Methode(n)

ELISA: suitable

Aufnahme

sample type plasma
sample type cell culture supernatant(s)
sample type serum

assay range

inter-assay cv: <12%
intra-assay cv: <10%

Versandbedingung

wet ice

Lagertemp.

−20°C

Angaben zum Gen

human ... IL12RB2(3595)

Allgemeine Beschreibung

The IL12RB2 (interleukin 12 receptor subunit β 2) gene is mapped to human chromosome 1p31.3 and codes for the β2 chain (130 kDa) of IL-12 receptor.
This ELISA antibody pair detects human IL-12 R beta 2. Other species not yet determined.

Anwendung

For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.

Biochem./physiol. Wirkung

Il12rb2 (interleukin 12 receptor subunit β 2) stimulates the release of interferon γ and Th1 (T helper cell 1) cell differentiation, as a part of autoimmune response. Il12rb2′s major function is associated with cell mediated immune system. In mice model, deletion of L12RB2 gene is associated with autoimmune and malignant disorders.

Sonstige Hinweise

A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.

Piktogramme

Corrosion
GHS05

Signalwort

Warning

H-Sätze

H290

P-Sätze

P234 - P390

Gefahreneinstufungen

Met. Corr. 1

Lagerklassenschlüssel

8A - Combustible corrosive hazardous materials

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Identification of susceptibility SNPs in IL10 and IL23R-IL12RB2 for Behcet's disease in Han Chinese.
Yu H, et al.
The Journal of Allergy and Clinical Immunology, 139(2), 621-627 (2017)
IL12RB2 Polymorphisms correlate with risk of lung adenocarcinoma.
Prigione I, et al.
Immunobiol., 221(2), 291-299 (2016)
Association study of rs924080 and rs11209032 polymorphisms of IL23R-IL12RB2 in a Northern Chinese Han population with Behcet?s disease.
Qin X, et al.
Human immunology, 77(12), 1284-1290 (2016)
An ankylosing spondylitis-associated genetic variant in the IL23R-IL12RB2 intergenic region modulates enhancer activity and is associated with increased Th1-cell differentiation.
Roberts A R, et al.
Annals of the Rheumatic Diseases (2016)
Nahoko Kato-Kogoe et al.
Immunogenetics, 68(1), 55-65 (2015-11-11)
Interleukin 12 receptor β chain (IL12RB2) is a crucial regulatory factor involved in cell-mediated immune responses, and genetic variants of the gene encoding IL12RB2 are associated with susceptibility to various immune-related diseases. We previously demonstrated that haplotypes with single nucleotide

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