O4636

Oxytetracyclin Dihydrat

Assay (anhydrous basis) 95.0%-102.0%

• Synonym(e): 5-Hydroxytetracycline dihydrate, Oxytetracycline, Oxytetracycline Anhydrous
• Empirische Formel (Hill-System): C₂₂H₂₄N₂O₉ · 2H₂O
• CAS-Nummer: 6153-64-6
• Molekulargewicht: 496.46
• EG-Nummer: 201-212-8
• MDL-Nummer: MFCD00151234
• UNSPSC-Code: 51284038
• PubChem Substanz-ID: 24898000
• NACRES: NA.85

Eigenschaften

• Qualitätsniveau: 200
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria
• Wirkungsweise: protein synthesis | interferes
• SMILES String: O.[H][C@@]12[C@@H](O)[C@@]3([H])C(C(=O)c4c(O)cccc4[C@@]3(C)O)=C(O)[C@]1(O)C(=O)C(C(N)=O)=C(O)[C@H]2N(C)C
• InChI: 1S/C22H24N2O9.H2O/c1-21(32)7-5-4-6-8(25)9(7)15(26)10-12(21)17(28)13-14(24(2)3)16(27)11(20(23)31)19(30)22(13,33)18(10)29;/h4-6,12-14,17,25,27-29,32-33H,1-3H3,(H2,23,31);1H2/t12-,13-,14+,17+,21-,22+;/m1./s1
• InChIKey: IBZHEBHGZFICKS-IFLJXUKPSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: tetracycline

Anwendung

Oxytetracycline is a tetracycline analog isolated from the actinomycete Streptomyces rimosus. It is used in studies on the oxytetracycline-resistance gene (otrA) and is used for fluorescence measurements of hepatocytes.

Biochem./physiol. Wirkung

Oxytetracycline inhibits translation, which results in cell death. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome, inhibiting protein synthesis (elongation). The binding is reversible in nature. Oxytetracycline is lipophilic so it can easily pass through a cell membrane and passively diffuses through channels in the bacterial membrane.

Antibiotic produced by Streptomyces rimosus.
Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit.
Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
Mode of Resistance: Active efflux, ribosome protection, tetracycline inactivation.

Hinweis zur Analyse

solubility very slightly solube in water, it dissolves in dilute acid and alkaline solutions

Sonstige Hinweise

10g,50g

Keep container tightly closed in a dry and well-ventilated place.

Sicherheitshinweise

• Piktogramme: GHS08,GHS09
• Signalwort: Warning
• H-Sätze: H361d,H411
• P-Sätze: P202 - P273 - P280 - P308 + P313 - P391 - P405
• Gefahreneinstufungen: Aquatic Chronic 2 - Repr. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)