L5420

Lumefantrin

• Synonym(e): (9Z)-2,7-Dichlor-9-[(4-chlorphenyl)-methylen]-α-[(dibutylamino)-methyl]-9H-fluoren-4-methanol, Benflumetol, CPG-56695
• Empirische Formel (Hill-System): C₃₀H₃₂Cl₃NO
• CAS-Nummer: 82186-77-4
• Molekulargewicht: 528.94
• MDL-Nummer: MFCD05662268
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329817625
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: yellow
• Löslichkeit: DMSO: 2 mg/mL, clear (warmed)
• Ersteller: Novartis
• Lagertemp.: room temp
• SMILES String: CCCCN(CCCC)CC(O)c1cc(Cl)cc2C(=C/c3ccc(Cl)cc3)\c4cc(Cl)ccc4-c12
• InChI: 1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15-
• InChIKey: DYLGFOYVTXJFJP-MYYYXRDXSA-N

Beschreibung

Allgemeine Beschreibung

Lumefantrine, also known as benflumetol is an aryl-amino alcohol. It is a member of the group of arylamine alcohols like quinine, mefloquine and halofantrine.

Anwendung

Lumefantrine has been used:
to study its effect on ex-vivo Plasmodium falciparum sensitivity using the tritiated hypoxanthine-based assay
as a standard in the quantification of combined tablet formulation using HPTLC
as a drug molecule in in vitro growth inhibition assay for in vitro B. caballi growth inhibition studies

Biochem./physiol. Wirkung

Lumefantrine is is an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.

Leistungsmerkmale und Vorteile

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable