K3644

K 858

≥98% (HPLC)

• Synonym(e): K858, N-(4-Acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadia zol-2-yl)acetamide
• Empirische Formel (Hill-System): C₁₃H₁₅N₃O₂S
• CAS-Nummer: 72926-24-0
• Molekulargewicht: 277.34
• MDL-Nummer: MFCD00181155
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 329817139
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to off-white
• Löslichkeit: DMSO: ≥20 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: CC(=O)NC1=NN(C(C)=O)C(C)(S1)c2ccccc2
• InChI: 1S/C13H15N3O2S/c1-9(17)14-12-15-16(10(2)18)13(3,19-12)11-7-5-4-6-8-11/h4-8H,1-3H3,(H,14,15,17)
• InChIKey: JEFVYQYZCAVNTP-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Eg5 is a key protein involved in the formation of bipolar spindles. K858 is a selective ATP-uncompetitive mitotic kinesin Eg5 inhibitor. The compound induces mitotic arrest, caspase-3 activation and cell growth inhibition in HCT116 cells.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable