I8026

Anti-Interleukin-8 antibody produced in goat

affinity isolated antibody, lyophilized powder

• Synonym(e): Anti-CXCL8
• MDL-Nummer: MFCD00212220
• UNSPSC-Code: 51111800
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: goat
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: lyophilized powder
• Speziesreaktivität: human
• Methode(n): immunocytochemistry: 5-15 μg/mL; immunohistochemistry: 5-15 μg/mL; neutralization: suitable; western blot: 0.1 μg/mL
• Lagertemp.: −20°C
• Angaben zum Gen: human ... IL8(3576)

Beschreibung

Allgemeine Beschreibung

Interleukin 8 (IL-8) is an 8kD, 72 amino acid residue containing cytokine that belongs to C-X-C chemokine family . The IL-8 gene is mapped to human chromosome 4q13.3.

Spezifität

The antibody will neutralize the biological activity of recombinant and natural human IL-8, but not recombinant human GROα.

Immunogen

recombinant human IL-8 (CXCL8).

Anwendung

Anti-Interleukin-8 antibody can be used for the following :

• For neutralizing the biological activity of recombinant human IL-8 and natural human IL-8.
• Immunoblotting.
• ELISA.

Anti-Interleukin-8 antibody can be used in immunocytochemistry and immunohistochemistry.

Biochem./physiol. Wirkung

Interleukin 8 (IL-8) stimulates neutrophils to produce lysosomal enzymes along with myeloperoxidase, α-mannosidase and β-glucuronidase . Goat anti-Interleukin-8 antibody reacts specifically with recombinant and natural human IL-8 but not with recombinant human GROα. Elevated expression of the gene is observed in a number of cancers including chronic spontaneous urticaria and breast cancer, thus serves as a prognostic marker for the same. IL-8 regulates the metastasis and angiogenesis processes during cancer development. IL-8 is responsible for epithelial–mesenchymal transition which plays an important role in providing cancer cells the mobility to invade other neighbouring cells, thereby contributing to metastasis.

Physikalische Form

Lyophilized from 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable