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Merck

K1001

Sigma-Aldrich

β-Estradiol-6-on

Synonym(e):

1,3,5-Oestradien-3,17β-diol-6-ol, 3,17β-Dihydroxy-1,3,5(10)-oestratrien-6-on, 6-Keto-oestradiol

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About This Item

Empirische Formel (Hill-System):
C18H22O3
CAS-Nummer:
Molekulargewicht:
286.37
Beilstein:
3208779
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77

Biologische Quelle

synthetic (organic)

Qualitätsniveau

Assay

≥98.00% (TLC)

Form

powder

Löslichkeit

chloroform: methanol (1:1): 19.60-20.40 mg/mL, clear, colorless to faintly yellow

Versandbedingung

ambient

Lagertemp.

room temp

SMILES String

C[C@]12CC[C@H]3[C@@H](CC(=O)c4cc(O)ccc34)[C@@H]1CC[C@@H]2O

InChI

1S/C18H22O3/c1-18-7-6-12-11-3-2-10(19)8-14(11)16(20)9-13(12)15(18)4-5-17(18)21/h2-3,8,12-13,15,17,19,21H,4-7,9H2,1H3/t12-,13-,15+,17+,18+/m1/s1

InChIKey

ZHTDDOWJIRXOMA-YVEZLPLXSA-N

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Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


Analysenzertifikate (COA)

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H Mikola et al.
Bioconjugate chemistry, 3(2), 182-186 (1992-03-01)
(Aminooxy)butyl- and -hexylamines and alcohols were synthesized by the Ing-Manske modification of the Gabriel synthesis. The aminooxy group of these heterobifunctional spacer reagents is a far more powerful nucleophile than the amino or hydroxy group because of the oxygen atom
N A Cridland et al.
The EMBO journal, 9(6), 1859-1866 (1990-06-01)
Photochemical excitation of a simple derivative of oestradiol using light in the UV-A range totally, permanently and selectively inactivates the oestrogen receptor protein present in a Xenopus liver extract without affecting its overall size. Inactivation of the binding site proceeds
M Numazawa et al.
Biochemical pharmacology, 47(4), 717-726 (1994-02-11)
Aromatase catalyzes the conversion of androst-4-ene-3,17-dione to estrogen through sequential oxygenations at the 19-methyl group. Androst-4-ene-3,6,17-trione (AT) is a suicide substrate of aromatase, and the mechanism of inactivation of aromatase has been postulated to involve enzymatic oxygenation at the 19-position.
M Adamczyk et al.
Steroids, 64(4), 283-290 (1999-07-10)
The 5 and 6-isomers of O-(fluoresceinylmethyl)hydroxylamine reacted with a representative sample of oxo-steroids (6-oxoestradiol, estrone, norethindrone, cortisol, progesterone, and digitoxin-dialdehyde) to produce O-(fluoresceinylmethyl)oxime conjugates in a single step in 24-84% yield after preparative high performance liquid chromotography.
Anna Bogucka-Kocka et al.
Journal of AOAC International, 94(1), 9-16 (2011-03-12)
Eighteen species belonging to the Carex genus were checked for the presence and the amount of eight phenolic acids (p-hydroxybenzoic, vanillic, caffeic, syringic, protocatechuic, p-coumaric, sinapic, and ferulic) by means of HPLC. Both the free and bonded phenolic acids were

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