I1877

Isocitronen-Dehydrogenase (NADP) aus Schweineherz

Type I, 0.5-3.0 unit/mg solid (plus numerous enzyme activities associated with porcine heart)

• Synonym(e): threo-D_s-Isocitrate: NADP⁺ oxidoreductase, ICDH, IDH
• CAS-Nummer: 9028-48-2
• EC-Nummer: 1.1.1.42 (BRENDA, IUBMB)
• EG-Nummer: 232-835-3
• MDL-Nummer: MFCD00131420
• UNSPSC-Code: 12352204
• NACRES: NA.54

Eigenschaften

• Biologische Quelle: Porcine heart
• Typ: Type I
• Form: solid
• Spezifische Aktivität: 0.5-3.0 unit/mg solid (plus numerous enzyme activities associated with porcine heart)
• Lagertemp.: −20°C

Beschreibung

Biochem./physiol. Wirkung

Isocitrate dehydrogenase (IDH) plays a major role in the Krebs cycle by catalyzing the oxidative decarboxylation of isocitrate. The oxidative decarboxylation of isocitrate generates α-ketoglutarate and NADPH. NADPH produced is essential for the production of fatty acids and cholesterol. This NADP-dependent molecules serves as homodimers.

Qualität

Crude

Einheitendefinition

One unit will convert 1.0 μmole of isocitrate to α-ketoglutarate per min at pH 7.4 at 37°C.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H334
• P-Sätze: P261 - P284 - P501
• Gefahreneinstufungen: Resp. Sens. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)