Direkt zum Inhalt
Merck

H9666

Sigma-Aldrich

Nerve Growth Factor β Human

HumanKine®, ≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture

Synonym(e):

NGF-β human

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise


About This Item

MDL-Nummer:
UNSPSC-Code:
12352202
NACRES:
NA.77

product name

Nerve Growth Factor β Human, NGF-β, recombinant, expressed in HEK 293 cells, HumanKine, suitable for cell culture

Biologische Quelle

human

Qualitätsniveau

Rekombinant

expressed in HEK 293 cells

Assay

≥95% (SDS-PAGE)

Form

lyophilized powder

Wirksamkeit

≤16 ng/mL ED50

Qualität

endotoxin tested

Mol-Gew.

13 kDa (non-glycosylated)

Verpackung

pkg of 10 μg

Hersteller/Markenname

HumanZyme

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

≤1 EU/μg

Lagertemp.

−20°C

Suchen Sie nach ähnlichen Produkten? Aufrufen Leitfaden zum Produktvergleich

Allgemeine Beschreibung

HumanKine NGF-β is expressed in human 293 cells as a non-glycosylated, non-disulfide bonded 13 kDa homodimer.

NGF-β belongs to the nerve growth factor protein superfamily. It is a key growth factor in target-mediated regulation of peripheral innervation. During development, NGF-β regulates nerve cell death, synaptic connectivity, fiber guidance, and dendritic morphology. The presence of NGF-β in immune cells and endocrine cells as well as in the CNS limbic areas suggests that it may function as an intracellular messenger to regulate the body′s response to stress.
The nerve growth factor β (NGFB) gene is mapped to human chromosome 1p13.2.

Anwendung

Nerve Growth Factor β Human has been used as a neurotrophic agent in luciferase reporter assay using mammalian cells.

Biochem./physiol. Wirkung

Nerve Growth Factor β (NGFB) acts as a key mediator in neuronal and non-neuronal development, differentiation, and survival. Polymorphism of NGFB gene leads to hereditary sensory and autonomic neuropathies. Charcot arthropathy and thermal insensitivity are few of the related symptoms. NGFB is known to promote cancer cell proliferation and metastasis. It is associated with lung, breast, prostatic and pancreatic cancers. In animal models, NGFB is observed to prevent cholinergic neuron loss and enhances memory.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution of 1X PBS

Hinweis zur Analyse

The specific activity was determined by the dose-dependent stimulation of the proliferation of the human TF-1 cells (human erythroleukemic indicator cell line).

Rechtliche Hinweise

3D Insert is a trademark of 3D Biotek, LLC
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Three-tier regulation of cell number plasticity by neurotrophins and Tolls in Drosophila
Foldi I, et al.
The Journal of Cell Biology, 20-26 (2017)
Three-tier regulation of cell number plasticity by neurotrophins and Tolls in Drosophila
Foldi I, et al.
The Journal of Cell Biology, jcb-201607098 (2017)
Three-tier regulation of cell number plasticity by neurotrophins and Tolls in Drosophila
Foldi I, et al.
The Journal of cell biology, 20-26 (2017)
Three-tier regulation of cell number plasticity by neurotrophins and Tolls in Drosophila
Foldi I, et al.
The Journal of cell biology, jcb-201607098 (2017)
A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
Tuszynski MH, et al.
Nature Medicine, 11(5), 551-551 (2005)

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.