GE17-5269-02

MabSelect^™ Xtra

Cytiva 17-5269-02, pack of 200 mL

• UNSPSC-Code: 41106500
• NACRES: NA.56

Eigenschaften

• ligand: recombinant protein A (E. coli)
• Verpackung: pack of 200 mL
• Hersteller/Markenname: Cytiva 17-5269-02
• Lagerbedingungen: (20% Ehtanol)
• Matrix: highly cross-linked agarose
• Durchschnittliche Teilgröße: 75 (d₅₀v is the median particle size of the cumulative volume distribution)
• cleaning in place: 2-12
• Arbeitsbereich: 3-10
• Kapazität: ≥30 mg binding capacity (humanlgG/ml at 2.4 min residence time)
• Eignung: suitable for bioprocess medium
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

Determined at 10% breakthrough by frontal analysis at a mobile phase velocity of 500 cm/h in a column with a bed height of 20 cm.

MabSelect^™ Xtra, with extra high dynamic binding capacity, is a member of the MabSelect^™ family. Developed to meet the demands of increasing levels of expression in monoclonal antibody feedstocks.

pH below 3 is sometimes required to elute strongly bound IgG species. However, protein ligands may hydrolyze at very low pH.

Anwendung

MabSelect^™ Xtra has the same recombinant Protein A ligand as MabSelect^™ but is based on a high-fLow Agarose base matrix with increased porosity and a slightly decreased particle size compared to MabSelect. This results in higher capacity—MabSelect^™ Xtra has about 30% higher dynamic binding capacity for IgG than currently available Protein A chromatography media. In addition, MabSelect^™ Xtra has a higher capacitiy for many Fc-fusion Proteins.

The medium provides a lower overall production cost due to the possibility of processing concentrated feedstocks in fewer batches.

MabSelect^™ Xtra is available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development. As member of the BioProcess media range, MabSelect^™ Xtra meets industrial demands with security of supply and comprehensive technical and regulatory support.

Leistungsmerkmale und Vorteile

• Higher dynamic binding capacity than currently available Protein A chromatography media.
• Improved process economics through reduced raw materials costs and/or reduced number of cycles
• High purity capture due to high ligand selectivity and matrix hydrophilicity
• Slightly lower pressure/fLow properties compared to MabSelect^™ SuRe^™ and MabSelect

Lagerung und Haltbarkeit

Please be aware this product may be shipped 90 days before the expiration date. For more information on the batch specific expiration date, please contact technical service.

Hinweis zur Analyse

To view the Certificate of Analysis for this product, please visit www.cytiva.com.

Rechtliche Hinweise

MabSelect is a trademark of Cytiva

SuRe is a trademark of Cytiva

Sicherheitshinweise

• Piktogramme: GHS02
• Signalwort: Warning
• H-Sätze: H226
• P-Sätze: P280 - P210 - P241 - P235 - P303 + P361 + P353 - P501
• Lagerklassenschlüssel: 3 - Flammable liquids