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G4013
Glutathione Peroxidase from human erythrocytes
lyophilized powder, ≥30 units/mg protein
Synonym(e):
Glutathione:hydrogen-peroxide oxido-reductase
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About This Item
Empfohlene Produkte
Form
lyophilized powder
Spezifische Aktivität
≥30 units/mg protein
Zusammensetzung
Protein, 13-25% modified Warburg-Christian
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−20°C
Angaben zum Gen
human ... GPX1(2876)
Allgemeine Beschreibung
GPX1 (glutathione peroxidase 1) belongs to the four membered family of GPXs, including GPX2, GPX3 and GPX4. It is a selenocysteine-containing protein. GPX1 is the major isoform of GPX enzyme and is ubiquitously present intracellularly.
Note: At the reported pH optimum of 8.8, we have found the activity to be approx. 10 times that at pH 7.0. However, to remain consistent with literature and avoid complications arising from non-enzymatic oxidation of GSH, our unit is defined at pH 7.0.
Anwendung
Glutathione peroxidase (GPX) from human erythrocytes has been used for the determination of the ability of peroxides to inactivate GPX in epithelial sheets obtained from cutaneous squamous cell carcinoma (CSCC) or solar keratoses (SK).
Biochem./physiol. Wirkung
GPX1 (glutathione peroxidase 1) catalyzes the conversion of multiple organic and inorganic peroxides, by utilizing reduced glutathione (GSH) as an electron donor. This enzyme is also responsible for the removal of organic and inorganic peroxides.
Einheitendefinition
One unit will catalyze the oxidation by H2O2 of 1.0 μmole of reduced glutathione to oxidized glutathione per min at pH 7.0 at 25 °C.
Physikalische Form
Lyophilized powder containing 25% sucrose, 3% dithiothreitol, and sodium phosphate buffer salts
Signalwort
Danger
H-Sätze
Gefahreneinstufungen
Resp. Sens. 1
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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Jennifer Walshe et al.
Cancer research, 67(10), 4751-4758 (2007-05-19)
Cutaneous squamous cell carcinomas (CSCC) are a common malignancy of keratinocytes that arise in sites of the skin exposed to excessive UV radiation. In the present study, we show that human SCC cell lines, preneoplastic solar keratoses (SK), and CSCC
O L Gostukhina et al.
Zhurnal evoliutsionnoi biokhimii i fiziologii, 48(6), 542-547 (2013-02-14)
The work studied the content of carotinoids, the state of antioxidant (AO) enzymatic complex, and intensity of lipid peroxidation in tissues (hepatopancreas, gill, foot) of the Black Sea bivalve mollusc Anadara inaequivalvis. Tissues with a high content of the pigment
Bing-Lin Zhang et al.
Environmental toxicology and chemistry, 32(6), 1420-1425 (2013-02-19)
The effect of sodium chloride (NaCl) on cadmium (Cd) uptake, translocation, and oxidative stress was investigated using 2 tobacco cultivars differing in Cd tolerance. The growth inhibition of the tobacco plants exposed to Cd toxicity was in part alleviated by
Hai-Dong Yao et al.
The Journal of nutrition, 143(5), 613-619 (2013-03-22)
Dietary selenium (Se) deficiency causes muscular dystrophy in various species, but the molecular mechanism remains unclear. Our objectives were to investigate: 1) if dietary Se deficiency induced different amounts of oxidative stress, lipid peroxidation, and cell apoptosis in 3 skeletal
Tengku Ahbrizal Farizal Tengku Ahmad et al.
Molecules (Basel, Switzerland), 18(2), 2200-2211 (2013-02-26)
The present study was designed to determine the radioprotective effects of Malaysian Gelam honey on gene expression and enzyme activity of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) of human diploid fibroblasts (HDFs) subjected to gamma-irradiation. Six groups
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