F8807

FM19G11

≥98% (HPLC)

• Synonym(e): 3-[(2,4-Dinitrobenzoyl)amino]-benzoic acid 2-(4-methylphenyl)-2-oxoethyl ester, [2-oxo-2-(p-tolyl)ethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate
• Empirische Formel (Hill-System): C₂₃H₁₇N₃O₈
• CAS-Nummer: 329932-55-0
• Molekulargewicht: 463.40
• MDL-Nummer: MFCD01174289
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329799774
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: off-white to light brown
• Löslichkeit: DMSO: ≥40 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: Cc1ccc(cc1)C(=O)COC(=O)c2cccc(NC(=O)c3ccc(cc3[N+]([O-])=O)[N+]([O-])=O)c2
• InChI: 1S/C23H17N3O8/c1-14-5-7-15(8-6-14)21(27)13-34-23(29)16-3-2-4-17(11-16)24-22(28)19-10-9-18(25(30)31)12-20(19)26(32)33/h2-12H,13H2,1H3,(H,24,28)
• InChIKey: XVUOIWIIQVGWAJ-UHFFFAOYSA-N

Beschreibung

Anwendung

FM19G11 has been used as ahypoxia-inducible factor-1α (HIF- 1α):

• to study the effects ofFM19G11-loaded gold nanoparticles (NPs) on self-renewal and proliferation of ependymal stem progenitor cells (epSPCs) of mice
• to study its effects on the O6-methylguanine DNA-methyltransferase (MGMT) expression in glioblastoma (GBM) cells
• to study its effects on microphthalmia-associated transcription factor (MITF) expression in melanoma cell line

Biochem./physiol. Wirkung

FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable