F8514

Flurbiprofen

cyclooxygenase inhibitor

• Synonym(e): (±)-2-Fluor-α-methyl-4-biphenyl-essigsäure, L-790,330
• Lineare Formel: C₆H₅C₆H₃(F)CH(CH₃)CO₂H
• CAS-Nummer: 5104-49-4
• Molekulargewicht: 244.26
• EG-Nummer: 225-827-6
• MDL-Nummer: MFCD00079303
• UNSPSC-Code: 51102829
• PubChem Substanz-ID: 24894968
• NACRES: NA.76

Eigenschaften

• Biologische Quelle: synthetic
• Qualitätsniveau: 100
• Assay: ≥98.5% (HPLC)
• Form: powder
• Farbe: white to off-white
• mp (Schmelzpunkt): 110-112 °C (lit.)
• Löslichkeit: methanol: 50 mg/mL
• Wirkungsspektrum von Antibiotika: fungi
• Wirkungsweise: enzyme | inhibits
• SMILES String: CC(C(O)=O)c1ccc(c(F)c1)-c2ccccc2
• InChI: 1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)
• InChIKey: SYTBZMRGLBWNTM-UHFFFAOYSA-N
• Angaben zum Gen: human ... ALB(213) , APP(351) , CYP1A2(1544) , CYP2C9(1559) , PTGS1(5742) , PTGS2(5743) ; rat ... Ptgs1(24693)

Beschreibung

Anwendung

Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic, analgesic, and antifungal activity. Oral formulations of flurbiprofen may be used to treat rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen is also used topically during ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to ibuprofen. It is used to study the pathophysiological steps of NSAID enteropathy in the rat and the biotransformation of flurbiprofen by Cunninghamella species.

Biochem./physiol. Wirkung

Fluibiprofen is a cyclooxygenase (COX) inhibitor, which is an enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This decreases the prostaglandins which cause inflammation, pain, swelling and fever. Flurbiprofen inhibits the activity of both COX-1 and -2. The S enantiomer inhibits prostaglandin synthesis and has both anti-inflammatory and analgesic activity, while the R enantiomer does not inhibit prostaglandin synthesis and displays only analgesic activity.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P264 - P270 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges