F7057
Folate Receptor 2 human
recombinant, expressed in CHO cells, ≥95% (SDS-PAGE)
Synonym(e):
FOLR2, Folate Receptor beta
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About This Item
UNSPSC-Code:
12352202
NACRES:
NA.56
Empfohlene Produkte
Biologische Quelle
human
Qualitätsniveau
Rekombinant
expressed in CHO cells
Assay
≥95% (SDS-PAGE)
Form
lyophilized
Verunreinigungen
≤1.0 EU/μg endotoxin
UniProt-Hinterlegungsnummer
Anwendung(en)
cell analysis
Lagertemp.
−20°C
Angaben zum Gen
human ... FOLR2(2350)
Anwendung
Folate Receptor 2 has been used in studies of the treatment of rheumatoid arthritis (RA) with Methotrexate (MTX). These studies have focused on transport of MTX through folate receptor 2 in RA synovial macrophages.
Biochem./physiol. Wirkung
Folate Receptor 2 is a 38kDa protein that has a high affinity for folic acid and mediates 5-methyltetrahydrofolate to the inside of the cell.
Physikalische Form
Lyophilized from PBS
Rekonstituierung
Reconstitute at 100 μg/ mL in PBS
Signalwort
Warning
H-Sätze
Gefahreneinstufungen
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Zielorgane
Respiratory system
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 2
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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C Fiehn
Clinical and experimental rheumatology, 28(5 Suppl 61), S40-S45 (2010-11-26)
Methotrexate (MTX) plays a pivotal role in the treatment of rheumatoid arthritis (RA). The transport mechanisms with which MTX reaches is target after application are an important part of MTX pharmacology and its concentration in target tissue such as RA
Andreas Wunder et al.
Journal of immunology (Baltimore, Md. : 1950), 170(9), 4793-4801 (2003-04-23)
We reported recently that albumin is a suitable drug carrier for targeted delivery of methotrexate (MTX) to tumors. Due to pathophysiological conditions in neoplastic tissue, high amounts of albumin accumulate in tumors and are metabolized by malignant cells. MTX, covalently
N Nakashima-Matsushita et al.
Arthritis and rheumatism, 42(8), 1609-1616 (1999-08-14)
To investigate the expression of folate receptors (FR) and reduced folate carrier (RFC) and determine their relevance to methotrexate (MTX) transport in synovial mononuclear cells (SMC) from patients with rheumatoid arthritis (RA). Levels of FR and RFC messenger RNA (mRNA)
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