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F5251

Sigma-Aldrich

p-Fluor-DL-phenylalanin

≥98.0% (TLC)

Synonym(e):

4-fluoro-phenylalanine

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About This Item

Lineare Formel:
FC6H4CH2CH(NH2)COOH
CAS-Nummer:
51-65-0
Molekulargewicht:
183.18
Beilstein:
2938793
EG-Nummer:
200-113-7
MDL-Nummer:
MFCD00002600
UNSPSC-Code:
12352209
eCl@ss:
32160406
PubChem Substanz-ID:
24894885
NACRES:
NA.26

product name

p-Fluor-DL-phenylalanin,

Assay

≥98.0% (TLC)

Qualitätsniveau

100

Form

powder

Farbe

white to off-white

mp (Schmelzpunkt)

253-255 °C (dec.) (lit.)

Anwendung(en)

peptide synthesis

SMILES String

NC(Cc1ccc(F)cc1)C(O)=O

InChI

1S/C9H10FNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)

InChIKey

XWHHYOYVRVGJJY-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

Inhibits mitosis and reversibly arrests HeLa cells in G2.
p-Fluoro-DL-phenylalanine (pFPhe), a toxic antimetabolite, is a racemic mixture of a substituted (halogenated) benzoyl D and L phenylalanine useful as a selection marker for wine yeast transformation and with potential use in endomorphin, antiviral, and antimicrobial drug development. Phenylalanine analogue, rho-fluorophenylalanine (pFPhe) is also used to induce apoptosis.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H300

Gefahreneinstufungen

Acute Tox. 2 Oral

Lagerklassenschlüssel

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Sigma-Aldrich

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Biochemical and biophysical research communications, 377(1), 280-285 (2008-10-11)
Phenylalanine analog, rho-fluorophenylalanine (pFPhe)-mediated cytotoxicity and several apoptotic events including mitochondrial cytochrome c release, activation of caspase-9, -3, and -8, Bid cleavage, degradation of PARP and PLCgamma-1, and DNA fragmentation were more significant in p56(lck)-deficient Jurkat T cells (JCaM1.6) than
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