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E5641

Sigma-Aldrich

11,12-Epoxy-(5Z,8Z,14Z)-eicosatrienoic acid

~100 μg/mL in ethanol, ≥95%

Synonym(e):

(±)11,12-EpETrE, 11,12-EET

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About This Item

Empirische Formel (Hill-System):
C20H32O3
CAS-Nummer:
123931-40-8
Molekulargewicht:
320.47
EG-Nummer:
200-578-6
MDL-Nummer:
MFCD00132914
UNSPSC-Code:
12352211
PubChem Substanz-ID:
24894343
NACRES:
NA.25

Qualitätsniveau

200

Assay

≥95%

Konzentration

~100 μg/mL in ethanol

Lipid-Typ

omega FAs

Lagertemp.

−20°C

SMILES String

CCCCC\C=C\CC1OC1C\C=C\C\C=C\CCCC(O)=O

InChI

1S/C20H32O3/c1-2-3-4-5-9-12-15-18-19(23-18)16-13-10-7-6-8-11-14-17-20(21)22/h6,8-10,12-13,18-19H,2-5,7,11,14-17H2,1H3,(H,21,22)/b8-6+,12-9+,13-10+

InChIKey

DXOYQVHGIODESM-ATELOPIESA-N

Verpackung

Packaged under argon

Piktogramme

FlameExclamation mark
GHS02,GHS07

Signalwort

Danger

H-Sätze

H225,H319

Gefahreneinstufungen

Eye Irrit. 2 - Flam. Liq. 2

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 1

Flammpunkt (°F)

48.2 °F - closed cup

Flammpunkt (°C)

9 °C - closed cup

Analysenzertifikate (COA)

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L Yang et al.
British journal of clinical pharmacology, 80(1), 28-44 (2015-02-07)
There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of cardiovascular risk
Yong Zhou et al.
Shock (Augusta, Ga.), 47(5), 638-645 (2016-10-19)
Acute lung injury (ALI) is characterized by rapid alveolar injury, vascular leakage, lung inflammation, neutrophil accumulation, and induced cytokines production leading to lung edema. The mortality rate of patients suffering from ALI remains high. Epoxyeicosatrienoic acids (EETs) are cytochrome P450-dependent
Huichen Zhao et al.
Laboratory investigation; a journal of technical methods and pathology, 97(7), 782-791 (2017-03-21)
Epoxyeicosatrienoic acids (EETs) are the epoxidation products of arachidonic acid catalyzed by cytochrome P450 (CYP) epoxygenases, which possess multiple biological activities. In the present study, we aimed to explore the role and effects of CYP epoxygenases/EETs in wound healing in
Yindi Ding et al.
The Journal of pharmacology and experimental therapeutics, 350(1), 14-21 (2014-04-26)
Cytochrome P450-derived epoxides of arachidonic acid [i.e., the epoxyeicosatrienoic acids (EETs)] are important lipid signaling molecules involved in the regulation of vascular tone and angiogenesis. Because many actions of 11,12-cis-epoxyeicosatrienoic acid (EET) are dependent on the activation of protein kinase
Jihong Lin et al.
Theranostics, 10(17), 7857-7871 (2020-07-21)
Rationale: Vasoregression secondary to glial activation develops in various retinal diseases, including retinal degeneration and diabetic retinopathy. Photoreceptor degeneration and subsequent retinal vasoregression, characterized by pericyte loss and acellular capillary formation in the absence diabetes, are also seen in transgenic
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