D9305

1-Desoxynojirimycin -hydrochlorid

• Synonym(e): 1,5-Dideoxy-1,5-imino-D-sorbit -hydrochlorid
• Empirische Formel (Hill-System): C₆H₁₃NO₄ · HCl
• CAS-Nummer: 73285-50-4
• Molekulargewicht: 199.63
• Beilstein: 3563225
• MDL-Nummer: MFCD00133247
• UNSPSC-Code: 12352201
• PubChem Substanz-ID: 24278397
• NACRES: NA.32

Eigenschaften

• Assay: ≥98% (TLC)
• Qualitätsniveau: 200
• Form: powder
• Löslichkeit: water: 19.60-20.40 mg/mL, clear, colorless
• Wirkungsspektrum von Antibiotika: viruses
• Wirkungsweise: enzyme | inhibits
• Lagertemp.: 2-8°C
• SMILES String: Cl[H].OC[C@H]1NC[C@H](O)[C@@H](O)[C@@H]1O
• InChI: 1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5-,6-;/m1./s1
• InChIKey: ZJIHMALTJRDNQI-VFQQELCFSA-N
• Angaben zum Gen: human ... GAA(2548)

Beschreibung

Allgemeine Beschreibung

Chemical structure: glucosamine

Anwendung

1-Deoxynojirimycin hydrochloride has been used

• to study its effects on the loss-of-function of N-glycosylation pathway on hair cell regeneration
• as an endoplasmic reticulum (ER) α-glucosidase I and II inhibitor to study its effects on TMED3-cystic fibrosis transmembrane conductance regulator (CFTR) interaction
• as an insect trehalase inhibitor in TREH inhibition bioassay

Biochem./physiol. Wirkung

1-Deoxynojirimycin (DNJ) is a naturally occurring alkaloid azasugar or iminosugar. It is observed in mulberry leaves, Commelina communis, and bacterial strains including Bacillus and Streptomyces species. DNJ acts as an α-glucosidase inhibitor and exhibits anti-viral anti-diabetic, anti-inflammatory, anti-obesity, and antioxidant properties.

α-Glucosidase-Inhibitor

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)