D1822

Doxycycline monohydrate

• Synonym(e): 6-Deoxy-5-oxytetracycline monohydrate, Doxycycline
• Empirische Formel (Hill-System): C₂₂H₂₄N₂O₈ · H₂O
• CAS-Nummer: 17086-28-1
• Molekulargewicht: 462.45
• MDL-Nummer: MFCD02682958
• UNSPSC-Code: 51284030
• PubChem Substanz-ID: 329798712
• NACRES: NA.85

Eigenschaften

• Form: powder or crystals
• Qualitätsniveau: 200
• Wirkungsspektrum von Antibiotika: Gram-negative bacteria; Gram-positive bacteria; mycoplasma; parasites
• Wirkungsweise: protein synthesis | interferes
• Lagertemp.: −20°C
• SMILES String: O.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c4c(O)cccc14
• InChI: 1S/C22H24N2O8.H2O/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25,27-29,32H,1-3H3,(H2,23,31);1H2/t7-,10+,14+,15-,17-,22-;/m0./s1
• InChIKey: XQTWDDCIUJNLTR-CVHRZJFOSA-N
• Angaben zum Gen: human ... MMP1(4312) , MMP13(4322) , MMP7(4316) , MMP8(4317)

Beschreibung

Anwendung

• In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).
• It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.
• It has also been used as an antimicrobial agent.

Biochem./physiol. Wirkung

Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 + P330 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable