D131

3,5-Dinitrocatechol

solid

• Synonym(e): 3,5-Dinitro-1,2-benzenediol, OR-486
• Empirische Formel (Hill-System): C₆H₄N₂O₆
• CAS-Nummer: 7659-29-2
• Molekulargewicht: 200.11
• MDL-Nummer: MFCD00069263
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24278158
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Assay: ≥98% (HPLC)
• Form: solid
• Farbe: yellow
• mp (Schmelzpunkt): 168-170 °C
• Löslichkeit: H₂O: slightly soluble 0.17 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.8 mg/mL; 0.1 M HCl: slightly soluble; DMSO: soluble; aqueous buffer pH > 5: soluble; ethanol: soluble
• Lagertemp.: 2-8°C
• SMILES String: Oc1cc(cc(c1O)[N+]([O-])=O)[N+]([O-])=O
• InChI: 1S/C6H4N2O6/c9-5-2-3(7(11)12)1-4(6(5)10)8(13)14/h1-2,9-10H
• InChIKey: VDCDWNDTNSWDFJ-UHFFFAOYSA-N
• Angaben zum Gen: human ... COMT(1312)

Beschreibung

Anwendung

3,5-Dinitrocatechol (3,5-DNC) has been used in the preparation of the molybdenum (VI)-(3,5-DNC) complex. It has also been used as a catechol-O-methyltransferase (COMT) inhibitor and as a positive control for screening human COMT inhibition.

Chelating reagent used in a sensitive (μM) assay for vanadium.

Biochem./physiol. Wirkung

Selective inhibitor of catechol O-methyl transferase (COMT); penetrates the blood brain barrier and is useful both orally and parenteraly in experiments where inhibition of COMT in the central nervous system is required.

Qualität

Solutions may be stored for several days at 4 °C.

Vorsicht

Photosensitive

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)