C8180

Cholera Toxin A Subunit from Vibrio cholerae

lyophilized powder

• MDL-Nummer: MFCD00130777
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Form: lyophilized powder
• Qualitätsniveau: 200
• Zusammensetzung: Protein, ~5% Lowry
• Verfügbarkeit: not available in Japan
• Verunreinigungen: ≤0.5% Cholera toxin B subunit (SDS-PAGE)
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

Cholera Toxin (CT) is secreted by Vibrio cholerae. CT upregulates cell surface molecules, such as co-stimulatory molecules and chemokine receptors in antigen presenting cells(APCs), murine and human dendritic cells (DCs). It enhances the secretion of interleukin 1 (IL-1) from macrophages and stimulates their APC function. CT also functions as an immunomodulator.

Anwendung

Cholera Toxin A Subunit from Vibrio cholerae has been used as a specific probe for trimeric G proteins in membrane motility assays.

Biochem./physiol. Wirkung

Catalyzes ADP-ribosylation of the α-subunit of G proteins, reducing GTPase activity and activating the α-subunit; also catalyzes ADP-ribosylation of cell membrane adenylyl cyclase

Physikalische Form

Lyophilized powder containing Tris buffer salts, sodium chloride, sodium azide and sodium EDTA

Rekonstituierung

When reconstituted with 1 mL of water, the solution will contain 0.05 M Tris buffer salts, pH 7.5, 0.2 M NaCl, 0.003 M NaN₃, and 0.001 M sodium EDTA. Store reconstituted solutions in the refrigerator.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H332,H412
• P-Sätze: P261 - P271 - P273 - P304 + P340 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Inhalation - Aquatic Chronic 3
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable