C7081

WY-14643

• Synonym(e): 4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid, Pirinixic acid
• Empirische Formel (Hill-System): C₁₄H₁₄ClN₃O₂S
• CAS-Nummer: 50892-23-4
• Molekulargewicht: 323.80
• MDL-Nummer: MFCD00191335
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24892928
• NACRES: NA.77

Eigenschaften

• Form: powder
• Qualitätsniveau: 100
• SMILES String: CC1=C(C)C=CC=C1NC2=NC(SCC(O)=O)=NC(Cl)=C2
• InChI: 1S/C14H14ClN3O2S/c1-8-4-3-5-10(9(8)2)16-12-6-11(15)17-14(18-12)21-7-13(19)20/h3-6H,7H2,1-2H3,(H,19,20)(H,16,17,18)
• InChIKey: SZRPDCCEHVWOJX-UHFFFAOYSA-N
• Angaben zum Gen: human ... PPARA(5465) , PPARD(5467) , PPARG(5468) ; mouse ... Ppara(19013) ; rat ... Ppara(25747)

Beschreibung

Allgemeine Beschreibung

WY-14643 prevents lipopolysaccharide (LPS)-induced inflammation in synovial fibroblasts. It protects cortical neurons from pro-inflammatory mediator-induced cell injuries. WY-14643 has inhibitory effects on pro-inflammatory responses in microglia. It improves oxido-nitrosative stress in disease models and reduces the generation of reactive oxygen species (ROS), nitric oxide (NO) and lipid peroxidation end-products in the brain.

Anwendung

WY-14643 has been used:

• as a positive control for transfection and luciferase assay
• to stimulate bone marrow–derived macrophages (BMDM) for autophagic flux analysis
• to analyze the regulation of fatty acid metabolism-immune nexus (FAMIN) expression in cell culture

Biochem./physiol. Wirkung

Selective PPARα agonist.

Leistungsmerkmale und Vorteile

This compound is featured on the Nuclear Receptors (Non-Steroids) and Nuclear Receptors (PPARs) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H302,H315,H319,H335,H350
• P-Sätze: P201 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges