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Merck

C4542

Sigma-Aldrich

Cyclobenzaprin -hydrochlorid

Synonym(e):

5-(3-Dimethylaminopropyliden)-dibenzo[a,e]cycloheptatrien -hydrochlorid

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About This Item

Empirische Formel (Hill-System):
C20H21N · HCl
CAS-Nummer:
Molekulargewicht:
311.85
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77

Form

powder

Qualitätsniveau

Ersteller

Johnson & Johnson

SMILES String

Cl.CN(C)CC\C=C1\c2ccccc2C=Cc3ccccc13

InChI

1S/C20H21N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-14H,7,15H2,1-2H3;1H

InChIKey

VXEAYBOGHINOKW-UHFFFAOYSA-N

Angaben zum Gen

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Allgemeine Beschreibung

Cyclobenzaprine is a tricyclic agent, which has anti-depressant and anti-cholinergic properties. It lowers the tonic somatic motor activity of motor neuron systems. Cyclobenzaprine prevents the uptake of noradrenaline. It is used to treat neck, back and myofascial pain. Cyclobenzaprine functions as a nerve impulse inhibitor.

Anwendung

Cyclobenzaprine hydrochloride has been used to study its effect on the muscles of dystrophin-deficient mdx5Cv mice.
Cyclobenzaprine hydrochloride has been used to study its effects on the muscles of dystrophin-deficient mdx5Cv mice.

Biochem./physiol. Wirkung

Relaxans der Skelett-Muskulatur; reduziert Muskelkrämpfe durch Depression von Neuronen des Hirnstamms; 5-HT2-Serotonin-Rezeptor-Antagonist.
Cyclobenzaprine hydrochloride is a type of tricyclic skeletal drug, which is commonly used as a muscle relaxant. It is very effective in treating intractable pain of cervical and lumbar origin caused by skeletal muscle spasm. cyclobenzaprine hydrochloride inhibit tonic α-mononeuronal excitation mediated by descending serotonergic systems by interacting with serotonin receptors at the spinal cord level.

Leistungsmerkmale und Vorteile

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Skull and crossbones

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Psychiatric Side Effects of Prescription and Over-the-counter Medications: Recognition and Management (1998)
Efficacy of a low-dose regimen of cyclobenzaprine hydrochloride in acute skeletal muscle spasm: results of two placebo-controlled trials
Borenstein DG and Korn S
Clinical Therapeutics, 25(4), 1056-1073 (2003)
A validated inherent stability indicating HPTLC method for estimation of cyclobenzaprine hydrochloride in tablets and use of MS-QTOF in characterization of its alkaline stress degradation product
Harde MT, et al.
Bulletin of Faculty of Pharmacy, Cairo University, 54(2), 145-156 (2016)
H Kobayashi et al.
European journal of pharmacology, 311(1), 29-35 (1996-09-05)
The centrally acting muscle relaxant cyclobenzaprine was thought to be an alpha 2-adrenoceptor agonist that reduced muscle tone by decreasing the activity of descending noradrenergic neurons. In the present study, we examined the effects of cyclobenzaprine on descending neurons by
Cyclobenzaprine in intractable pain syndromes with muscle spasm
Brown BR and Womble J
JAMA : The Journal of the American Medical Association, 240(11), 1151-1152 (1978)

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