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C1305

Sigma-Aldrich

Cafestol acetate

≥98%

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About This Item

Empirische Formel (Hill-System):
C22H30O4
CAS-Nummer:
81760-48-7
Molekulargewicht:
358.47
MDL-Nummer:
MFCD00133152
UNSPSC-Code:
12352205
PubChem Substanz-ID:
24892399
NACRES:
NA.79

Assay

≥98%

Form

powder

Methode(n)

HPLC: suitable

Farbe

white to off-white

Lagertemp.

2-8°C

SMILES String

CC(=O)OCC1(O)CC23CCC4c5ccoc5CCC4(C)C2CCC1C3

InChI

1S/C22H30O4/c1-14(23)26-13-22(24)12-21-9-5-17-16-7-10-25-18(16)6-8-20(17,2)19(21)4-3-15(22)11-21/h7,10,15,17,19,24H,3-6,8-9,11-13H2,1-2H3

InChIKey

PTGGVIKFNQSFBY-UHFFFAOYSA-N

Anwendung

Cafestol acetate has been used to determine the effects of coffee on heat shock response (HSR).

Biochem./physiol. Wirkung

Cafestol is a coffee-specific diterpene. It has anti-carcinogenic and anti-inflammatory activities. Cafestol stimulates apoptosis in cells associated with colorectal and renal cancer (Caki cells). It is used to study mechanisms of anti-oxidation related to hydrogen peroxide induced oxidative stress and DNA damage. Cafestol increases the level of glutathione (GSH), by stimulating γ-glutamylcysteine synthetase. It acts as a chemopreventive agent by inducing cytochrome P-450.

Sonstige Hinweise

Furan-containing diterpene from green coffee beans.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Pablo Muriel et al.
Fitoterapia, 81(5), 297-305 (2009-10-15)
Coffee consumption is worldwide spread with few side effects. Interestingly, coffee intake has been inversely related to the serum enzyme activities gamma-glutamyltransferase, and alanine aminotransferase in studies performed in various countries. In addition, epidemiological results, taken together, indicate that coffee
Ting Shen et al.
Biological & pharmaceutical bulletin, 33(1), 128-132 (2010-01-05)
Coffee is a popular beverage worldwide with various nutritional benefits. Diterpene cafestol, one of the major components of coffee, contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects. In this study
Kyung Jin Lee et al.
Toxicology letters, 173(2), 80-87 (2007-08-11)
There is an increasing evidence that oxidative stress is implicated in the processes of inflammation and carcinogenesis. It has been shown that kahweol and cafestol, coffee-specific diterpenes, exhibit chemoprotective effects. This study investigated the effects of kahweol and cafestol, coffee-specific
Use of silver nitrate impregnated silica cartridges in the separation of kahweol and cafestol esters by preparative liquid chromatography.
L K Lam et al.
Journal of chromatography, 328, 422-424 (1985-06-28)
Kai-Shan Tao et al.
Medical hypotheses, 71(5), 730-736 (2008-08-15)
Epidemiological studies have found an inverse association between coffee consumption and the risk of liver cancer. Animal data support such a chemopreventive effect of coffee. Substantial research has been devoted to the identification of coffee components that may be responsible
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