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B3770

Sigma-Aldrich

(+)-Biotinamidohexansäurehydrazid

≥90% (TLC), powder

Synonym(e):

(+)-Biotin-ε-aminocaproyl-hydrazid, (+)-Biotinamidocaproyl-hydrazid, BACH

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About This Item

Empirische Formel (Hill-System):
C16H29N5O3S
CAS-Nummer:
109276-34-8
Molekulargewicht:
371.50
MDL-Nummer:
MFCD00077659
UNSPSC-Code:
12352125
eCl@ss:
34058011
PubChem Substanz-ID:
24891734
NACRES:
NC.07

Assay

≥90% (TLC)

Form

powder

Löslichkeit

DMSO: 25 mg/mL

Lagertemp.

2-8°C

SMILES String

[H][C@]12CS[C@@H](CCCCC(=O)NCCCCCC(=O)NN)[C@@]1([H])NC(=O)N2

InChI

1S/C16H29N5O3S/c17-21-14(23)8-2-1-5-9-18-13(22)7-4-3-6-12-15-11(10-25-12)19-16(24)20-15/h11-12,15H,1-10,17H2,(H,18,22)(H,21,23)(H2,19,20,24)/t11-,12-,15-/m0/s1

InChIKey

IJJWOSAXNHWBPR-HUBLWGQQSA-N

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Anwendung

Biotinylation reagent with aminocaproic spacer for aldehyde groups (e.g., periodate-oxidized sugars) and carboxylic acids. Typically used for coupling to glycoproteins through the carbohydrate by hydrazone bond formation.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Adelaide U P Hain et al.
Journal of medicinal chemistry, 57(11), 4521-4531 (2014-05-03)
Atg8 is a ubiquitin-like autophagy protein in eukaryotes that is covalently attached (lipidated) to the elongating autophagosomal membrane. Autophagy is increasingly appreciated as a target in diverse diseases from cancer to eukaryotic parasitic infections. Some of the autophagy machinery is
M B Rosenberg et al.
Journal of neurochemistry, 46(2), 641-648 (1986-02-01)
beta-nerve growth factor (NGF) was modified by biotinylation via carboxyl group substitution (C-bio-NGF) using biotin hydrazide and the coupling reagent 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide, under reaction conditions that yielded an average of 3 biotin additions per NGF subunit. NGF was also biotinylated through
S Spiegel et al.
Journal of immunology (Baltimore, Md. : 1950), 127(2), 572-575 (1981-08-01)
Biotin hydrazide was attached covalently to the aldehyde groups produced by periodate oxidation of bovine brain gangliosides. These modified gangliosides were incorporated into mature rat thymocytes by incubation of the biotinyl gangliosides in the culture medium containing these cells. Avidin
A new biotinylating system for DNA using biotin aminocaproyl hydrazide and glutaraldehyde.
T Takahashi et al.
Nucleic acids research, 17(12), 4899-4900 (1989-06-26)
Kimberly MacKay et al.
Briefings in functional genomics, 19(4), 292-308 (2020-05-01)
The advent of high-resolution chromosome conformation capture assays (such as 5C, Hi-C and Pore-C) has allowed for unprecedented sequence-level investigations into the structure-function relationship of the genome. In order to comprehensively understand this relationship, computational tools are required that utilize
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