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Merck
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Key Documents

B1814

Sigma-Aldrich

BMP2, human

Carrier Free, ≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Synonym(e):

BMP-2

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About This Item

MDL-Nummer:
MFCD03097877
UNSPSC-Code:
12352202
NACRES:
NA.32

product name

Morphogenetisches Knochenprotein 2 human, Carrier Free, ≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Biologische Quelle

human

Qualitätsniveau

200

Rekombinant

expressed in E. coli

Assay

≥98% (SDS-PAGE)

Form

lyophilized powder

Mol-Gew.

26 kDa

Verpackung

pkg of 10 μg

Lagerbedingungen

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

Endotoxin, tested

Farbe

white

Löslichkeit

water: soluble 0.100 mL, clear, colorless

UniProt-Hinterlegungsnummer

P12643

Lagertemp.

−20°C

Angaben zum Gen

human ... BMP2(650)

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Biochem./physiol. Wirkung

Cellular responses to BMP-2 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. BMPs stimulate angiogenesis by inducing the production of VEGF-A by osteoblasts. Human, mouse, and rat BMP-2 demonstrate 100% homology.

Physikalische Form

Lyophilized from a 0.2 μm filtered buffered solution.

Hinweis zur Analyse

The biological activity is measured by its ability to induce alkaline phosphatase production by ATDC5 chondrogenic cells.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

104.0 °F - closed cup

Flammpunkt (°C)

40.0 °C - closed cup

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Ernst B Hunziker et al.
Tissue engineering. Part A, 21(13-14), 2089-2098 (2015-04-22)
The articular cartilage layer of synovial joints is commonly lesioned by trauma or by a degenerative joint disease. Attempts to repair the damage frequently involve the performance of autologous chondrocyte implantation (ACI). Healthy cartilage must be first removed from the
Fengxuan Han et al.
Journal of biomedical materials research. Part B, Applied biomaterials, 103(7), 1344-1353 (2014-11-12)
Repair of cartilage-bone interface tissue remains challenging, because it combines different cell types and gradients of composition and properties. To enable simultaneous regeneration of bone, cartilage, and especially their interface, a conically graded scaffold of chitosan-gelatin hydrogel/poly(l-lactide-co-glycolide) (PLGA) was facilely
Lindsay A Bonsignore et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(7), 979-987 (2015-02-14)
The most important factor contributing to short-term and long-term success of cementless total joint arthroplasties is osseointegration. Osseointegration leads to a direct structural and functional connection between living bone and the surface of an implant. Surface contaminants may remain on
Thorsten Pfirrmann et al.
Human molecular genetics, 24(11), 3119-3132 (2015-02-26)
Chordin-Like 1 (CHRDL1) mutations cause non-syndromic X-linked megalocornea (XMC) characterized by enlarged anterior eye segments. Mosaic corneal degeneration, presenile cataract and secondary glaucoma are associated with XMC. Beside that CHRDL1 encodes Ventroptin, a secreted bone morphogenetic protein (BMP) antagonist, the
Liping Wang et al.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(8), 1212-1217 (2015-03-17)
Available evidence indicates that some Tie2-expressing (Tie2(+) ) cells serve as multipotent progenitors that have robust BMP-dependent osteogenic activity and mediate heterotopic ossification (HO). Since signaling through the G protein Gi is required for cell motility, we hypothesized that blockade
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