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A7000

Sigma-Aldrich

Acetylcholiniodid

≥97%

Synonym(e):

ACh

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About This Item

Lineare Formel:
(CH3)3N(I)CH2CH2OCOCH3
CAS-Nummer:
2260-50-6
Molekulargewicht:
273.11
Beilstein:
3571339
EG-Nummer:
218-862-3
MDL-Nummer:
MFCD00011815
UNSPSC-Code:
12352107
PubChem Substanz-ID:
24891162
NACRES:
NA.25

Qualitätsniveau

200

Assay

≥97%

Form

powder

Lagertemp.

−20°C

SMILES String

[I-].CC(=O)OCC[N+](C)(C)C

InChI

1S/C7H16NO2.HI/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1

InChIKey

SMBBQHHYSLHDHF-UHFFFAOYSA-M

Angaben zum Gen

human ... CHRM3(1131)

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Anwendung

Acetylcholine is an endogenous neurotransmitter at cholinergic synapses that amplifies action potential of the sarcolemma thereby inducing muscle contractions. Acetylcholine iodide is used as an acetylcholine receptor agonist to identify, characterize and differentiate among types of cholinergic receptors. Acetylcholine iodide is used as a substrate to identify and characterize natural and mutated acetylcholinesterase(s).

Biochem./physiol. Wirkung

Endogener Neurotransmitter in cholinergenen Synapsen; verstärkt das Aktionspotential am Sarcolemma und ruft dadurch Muskelkontraktionen hervor.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Iryna Andrusenko et al.
Angewandte Chemie (International ed. in English), 58(32), 10919-10922 (2019-06-19)
Orthocetamol is a regioisomer of the well-known pain medication paracetamol and a promising analgesic and an anti-arthritic medicament itself. However, orthocetamol cannot be grown as single crystals suitable for X-ray diffraction, so its crystal structure has remained a mystery for
Marie Briet et al.
Journal of the American Heart Association, 2(2), e000128-e000128 (2013-04-16)
Recent studies have raised concern about the safety of erythropoiesis-stimulating agents because of evidence of increased risk of hypertension and cardiovascular morbidity and mortality in chronic kidney disease (CKD) patients. In the present study, we investigated the effects of recombinant
Tracey Huynh et al.
Journal of medicinal chemistry, 56(20), 8196-8200 (2013-10-01)
The M4 mAChR is implicated in several CNS disorders and possesses an allosteric binding site for which ligands modulating the affinity and/or efficacy of ACh may be exploited for selective receptor targeting. We report the synthesis of a focused library
Wei Wang et al.
Journal of biomedical nanotechnology, 9(4), 736-740 (2013-04-30)
A novel type of acetylcholine electrochemical biosensor was successfully fabricated by dropping beta-cyclodextrin solution, acetylcholinesterase solution and Nafion-methanol solution to the homemade nano-porous pseudo carbon paste electrode (nano-PPCPE) as working electrode, and then the electrochemical behavior of the as-prepared biosensor
Carolina Wedemeyer et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(39), 15477-15487 (2013-09-27)
The synapse between olivocochlear (OC) neurons and cochlear mechanosensory hair cells is cholinergic, fast, and inhibitory. The inhibitory sign of this cholinergic synapse is accounted for by the activation of Ca(2+)-permeable postsynaptic α9α10 nicotinic receptors coupled to the opening of
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