A6060

Calpain-Inhibitor II

powder

• Synonym(e): N-Acetyl-L-leucyl-L-leucyl-L-methioninal
• Empirische Formel (Hill-System): C₁₉H₃₅N₃O₄S
• CAS-Nummer: 110115-07-6
• Molekulargewicht: 401.56
• Beilstein: 7693643
• MDL-Nummer: MFCD00065506
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24891051
• NACRES: NA.77

Eigenschaften

• Assay: ≥95% (HPLC)
• Form: powder
• Farbe: white
• Löslichkeit: ethanol: 20 mg/mL
• Lagertemp.: −20°C
• SMILES String: [H]C(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O
• InChI: 1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1
• InChIKey: RJWLAIMXRBDUMH-ULQDDVLXSA-N

Beschreibung

Anwendung

Calpain Inhibitor II has been used in western blotting. It has also been used to study the mechanism of Spy1A (a cyclin-like protein) degradation during cell cycle.

Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.

Biochem./physiol. Wirkung

Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.

Sonstige Hinweise

Formerly CAS# 136632-32-1

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)