A2979

A-317491 sodium salt hydrate

≥98% (HPLC), powder

• Synonym(e): 5-[[[(3-Phenoxyphenyl)methyl][(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]amino]carbonyl]-1,2,4-benzenetricarboxylic acid sodium salt hydrate
• Empirische Formel (Hill-System): C₃₃H₂₇NO₈ · xNa⁺ · yH₂O
• Molekulargewicht: 565.57 (anhydrous free acid basis)
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329770806
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: H₂O: 15 mg/mL, clear
• Ersteller: Abbott
• SMILES String: [Na].[H]O[H].OC(=O)c1cc(C(O)=O)c(cc1C(O)=O)C(=O)N(Cc2cccc(Oc3ccccc3)c2)[C@H]4CCCc5ccccc45
• InChI: 1S/C33H27NO8.Na.H2O.H/c35-30(25-17-27(32(38)39)28(33(40)41)18-26(25)31(36)37)34(29-15-7-10-21-9-4-5-14-24(21)29)19-20-8-6-13-23(16-20)42-22-11-2-1-3-12-22;;;/h1-6,8-9,11-14,16-18,29H,7,10,15,19H2,(H,36,37)(H,38,39)(H,40,41);;1H2;/t29-;;;/m0.../s1
• InChIKey: VEMCGHRDAPMXLI-VYEUTZPBSA-N

Beschreibung

Anwendung

A-317491 sodium salt hydrate has been used to block the P2X3 receptor. It has also been used to block the increased membrane conductance.

Biochem./physiol. Wirkung

A-317491 helps to decrease neuropathic and inflammatory pain by inhibiting the P2X3 receptor-mediated Ca²⁺ influx.

Novel P2X₃ and P2X_2/3 receptor antagonist

Leistungsmerkmale und Vorteile

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Rechtliche Hinweise

Subject to U.S. Patent No. 6,831,193. Sold under license from Abbott Laboratories

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)