A1276

Amastatin -hydrochlorid

powder, ≥97% (HPLC)

• Synonym(e): N-[(2S,3R)-3-Amino-2-hydroxy-5-methylhexanoyl]-L-valyl-L-valyl-L-asparaginsäure -hydrochlorid Hydrat
• Empirische Formel (Hill-System): C₂₁H₃₈N₄O₈ · HCl · xH₂O
• CAS-Nummer: 100938-10-1
• Molekulargewicht: 511.01 (anhydrous basis)
• Beilstein: 8888370
• MDL-Nummer: MFCD00150636
• UNSPSC-Code: 12352202
• PubChem Substanz-ID: 24890521
• NACRES: NA.77

Eigenschaften

• product name: Amastatin -hydrochlorid, ≥97% (HPLC)
• Biologische Quelle: synthetic (organic)
• Qualitätsniveau: 200
• Assay: ≥97% (HPLC)
• Form: powder
• mp (Schmelzpunkt): 202-205 °C
• Löslichkeit: methanol: 1 mM (Stock solution stable for 1 month at −20 °C. Working solution stable for 1 day.)
• Wirkungsspektrum von Antibiotika: neoplastics
• Wirkungsweise: enzyme | inhibits
• Lagertemp.: −20°C
• SMILES String: Cl[H].[H]O[H].CC(C)C[C@@H](N)[C@H](O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O
• InChI: 1S/C21H38N4O8.ClH.H2O/c1-9(2)7-12(22)17(28)20(31)25-16(11(5)6)19(30)24-15(10(3)4)18(29)23-13(21(32)33)8-14(26)27;;/h9-13,15-17,28H,7-8,22H2,1-6H3,(H,23,29)(H,24,30)(H,25,31)(H,26,27)(H,32,33);1H;1H2/t12-,13+,15+,16+,17+;;/m1../s1
• InChIKey: WBYDQJQQTMJMQH-AFROIDPFSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: peptide

Biochem./physiol. Wirkung

It inhibits cytosolic leucine aminopeptidase (EC.3.4.11.1), microsomal aminopeptidase M (EC.3.4.11.2) and bacterial leucine aminopeptidase (EC.3.4.11.10). It is less effective against aminopeptidase A (EC 3.4.11.7), the enzyme that converts angiotensin II to angiotensin III. Potentiates the CNS effects of vasopressin and oxytocin in vivo.

Effective concentration: 1-10 μM.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)