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Merck

53370

Sigma-Aldrich

L-Histidin -monohydrochlorid Monohydrat

≥99.0% (AT)

Synonym(e):

L-α-Amino-β-(4-imidazolyl)propionic acid monohydrochloride

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About This Item

Empirische Formel (Hill-System):
C6H9N3O2 · HCl · H2O
CAS-Nummer:
Molekulargewicht:
209.63
Beilstein:
4168261
MDL-Nummer:
UNSPSC-Code:
12352209
PubChem Substanz-ID:
NACRES:
NA.77

Qualitätsniveau

Assay

≥99.0% (AT)

Form

solid

Optische Aktivität

[α]20/D +9.5±0.5°, c = 5% in 5 M HCl

Verunreinigungen

≤0.3% foreign amino acids

mp (Schmelzpunkt)

254 °C (dec.) (lit.)

Löslichkeit

H2O: 1 g/10 mL, clear, colorless (hot)

Anionenspuren

sulfate (SO42-): ≤100 mg/kg

Kationenspuren

Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
NH4+: ≤500 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

SMILES String

O.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2.ClH.H2O/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);1H;1H2/t5-;;/m0../s1

InChIKey

CMXXUDSWGMGYLZ-XRIGFGBMSA-N

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Allgemeine Beschreibung

L-Histidine is a hydrophilic essential amino acid that has a basic sidechain containing an imidazole group.

Biochem./physiol. Wirkung

L-Histidine is biosynthesized from ATP, 5-phosphoribosyl-1-pyrophosphate (PRPP), and glutamine. This essential amino acid can be degraded to glutamate by histidiase, urocanase and imidazolonepropionase; it is also the precursor of histamine by action of histidine decarboxylase.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Bio-protocol, 7(23), e2634-e2634 (2017-12-05)
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Neurochemistry international, 85-86, 31-39 (2015-05-06)
The effect of reserpine on histamine (HA) and tele-methylhistamine (N(τ)-MHA) in hypothalamus and cortex of rats was analyzed and compared to catecholamines. IP injection of reserpine (5 mg/kg) confirmed the effectiveness of reserpine treatment on noradrenaline and dopamine levels. Our in-vitro
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Journal of pharmaceutical sciences, 104(4), 1440-1450 (2015-01-22)
In a typical manufacturing setup for biopharmaceutical drug products, the fill and dosing pump is placed after the final sterile filtration unit in order to ensure adequate dispensing accuracy and avoid backpressure peaks. Given the sensitivity of protein molecules, peristaltic
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