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Key Documents

284M-9

Sigma-Aldrich

Microphthalmia Transcription Factor (MiTF) (C5/D5) Mouse Monoclonal Antibody

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100
500

Konjugat

unconjugated

Antikörperform

culture supernatant

Antikörper-Produkttyp

primary antibodies

Klon

C5/D5, monoclonal

Beschreibung

For In Vitro Diagnostic Use in Select Regions (See Chart)

Form

buffered aqueous solution

Speziesreaktivität

human

Verpackung

vial of 0.1 mL concentrate (284M-94)
vial of 0.5 mL concentrate (284M-95)
bottle of 1.0 mL predilute (284M-97)
vial of 1.0 mL concentrate (284M-96)
bottle of 7.0 mL predilute (284M-98)

Hersteller/Markenname

Cell Marque™

Methode(n)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Isotyp

IgG1

Kontrolle

melanoma

Versandbedingung

wet ice

Lagertemp.

2-8°C

Visualisierung

nuclear

Angaben zum Gen

human ... MITF(4286)

Allgemeine Beschreibung

Mi is a transcription factor implicated in pigmentation, bone development and in mast cells. Various forms of Mi exist ranging from 50-70 kD in size. This antibody targets the 52-56 kD range. This antibody has been useful in identifying malignant melanoma, and distinguishing mast cell lesions from lesions of myeloid derivation. A relatively rare class of tumors known as PEComas (tumors showing perivascular epithelioid cell differentiation) express MiTF in a high percentage of cases (~90%).

Qualität


IVD
IVD
IVD
RUO

Verlinkung

Microphthalmia Transcription Factor (MiTF) Positive Control Slides, Product No. 284S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physikalische Form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Angaben zur Herstellung

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Sonstige Hinweise

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Rechtliche Hinweise

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Die Dokumentenbibliothek aufrufen

Bernadette Liegl et al.
The American journal of surgical pathology, 32(4), 608-614 (2008-02-19)
PEComas arising in somatic soft tissue or skin are rare. To further characterize the clinicopathologic spectrum, we herein report a series of 10 primary cutaneous PEComas. Eight patients were female and 2 patients were male. The age at presentation ranged
Ilan Weinreb et al.
Virchows Archiv : an international journal of pathology, 450(4), 463-470 (2007-03-23)
Four cases of malignant PEComas were stained with smooth muscle actin, muscle specific actin, desmin, human melanoma black-45, melan-A, microphthalmia transcription factor, S100 and cyclin D1. One case was studied by electron microscopy (EM). Tumour locations were the thigh, elbow
Alberto Righi et al.
International journal of surgical pathology, 16(1), 16-20 (2008-01-22)
We report 2 cases of PEComa, one occurring in the colon of an 11-year-old boy and the other in the bone (fibula) of a 92-year-old woman. Both tumors consisted of nests of large epithelioid cells surrounded by a fibrovascular stroma.
Jason L Hornick et al.
The American journal of surgical pathology, 32(4), 493-501 (2008-01-29)
PEComas (tumors showing perivascular epithelioid cell differentiation) are a family of mesenchymal neoplasms that include angiomyolipoma, clear cell "sugar" tumor of the lung, lymphangiomyomatosis, and a group of uncommon lesions that arise in soft tissue, visceral organs, and skin. We
Steven J Ohsie et al.
Journal of cutaneous pathology, 35(5), 433-444 (2008-04-11)
Melanoma has a wide spectrum of histologic features which mimic epithelial, hematologic, mesenchymal, and neural tumors. Immunohistochemistry has been the primary tool to distinguish melanomas from these other tumors; it has also been studied for use as an adjunct to

Artikel

Immunohistochemistry: Current Applications in Skin Cancer

Immunohistochemistry (IHC) techniques and applications have greatly improved, dermatopathology is still largely based on H&E stained slides.This paper outlines ways in which IHC antibodies can be utilized for dermatopathology.

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