00541

Rutheniumrot

for microscopy, 85.0-115.0% (calc. on dry basis, AT)

• Synonym(e): Ammonisiertes Rutheniumoxychlorid
• Lineare Formel: [(NH₃)₅RuORu(NH₃)₄ORu(NH₃)₅]Cl₆
• CAS-Nummer: 11103-72-3
• Molekulargewicht: 786.35
• Farbindexnummer: 77800
• MDL-Nummer: MFCD00011479
• UNSPSC-Code: 12171500
• PubChem Substanz-ID: 329747091
• NACRES: NA.47

Eigenschaften

• Qualität: for microscopy
• Qualitätsniveau: 100
• Assay: 85.0-115.0% (calc. on dry basis, AT)
• Form: powder
• Verunreinigungen: ~5% water
• Löslichkeit: water: 10 mg/mL, clear to turbid
• εmax: ≥150 at 529-539 nm
• Anwendung(en): diagnostic assay manufacturing; hematology; histology
• Lagertemp.: room temp
• SMILES String: N.N.N.N.N.N.N.N.N.N.N.N.N.N.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Cl-].[Ru++]O[Ru++]O[Ru++]
• InChI: 1S/6ClH.14H3N.2O.3Ru/h6*1H;14*1H3;;;;;/q;;;;;;;;;;;;;;;;;;;;;;3*+2/p-6
• InChIKey: ZXYSDUPLHOJIOR-UHFFFAOYSA-H

Beschreibung

Allgemeine Beschreibung

Ruthenium red is an inorganic cationic dye. It is also known as ammoniated ruthenium oxychloride. It is a large coordination complex consisting of three metal atoms connected by bridging oxygens, in addition to multiple amine ligands.

Anwendung

Ruthenium red is suitable for use in light microscopy to stain pectins. It is also used to stain glycosaminoglycans by employing a two-color staining method with alcian blue. It serves as a typical basic dye at a higher pH that stains nuclei, Nissl substance, cartilage matrix, and mast cell granules. Other applications involving light microscopy include staining resin-embedded material. Ruthenium red is an important component of fixatives of the bacterial glycocalyx.

Hemmt mitochondrialen Ca²⁺ Uniporter; Capsaicin-Antagonist, blockiert VR1 Vanilloid-Rezeptor-gekoppelte Ionenkanäle.

Biochem./physiol. Wirkung

Ruthenium red inhibits mitochondrial Ca2+ uniporter. It is a known capsaicin antagonist. Additionally, it is known to block VR1 vanilloid receptor-coupled ion channels.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable