SMB00908
4-Hydroxy-4-methyl-2-oxoglutaric acid dipotassium salt
95-105% (titration)
Synonym(e):
4-Hydroxy-4-methyl-2-oxoglutaric acid dipotassium salt, Parapyruvate
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About This Item
Empfohlene Produkte
Assay
95-105% (titration)
Form
powder
Farbe
white to beige
Löslichkeit
water: soluble 10 mg/mL
Allgemeine Beschreibung
Parapyruvate, also known as 4-hydroxy-4-methyl-2-oxoglutarate (HMOG), is a compound formed through the polymerization of two molecules of pyruvate via aldol condensation. It is closely related to α-ketoglutarate and is believed to act as a competitive inhibitor of the α-Ketoglutarate dehydrogenase complex (KGDHC) to form succinyl coenzyme A, impacting fibroblast senescence. A decrease in KGDHC activity is also associated with neurodegenerative disorders such as Alzheimer′s and Parkinson′s diseases. The precise mechanism of parapyruvate′s inhibition of KGDHC is complex, but it interferes with the activity of this rate-limiting enzyme in the tricarboxylic acid (TCA) cycle, ultimately affecting mitochondrial function. KGDHC is crucial for oxidative decarboxylation within the TCA cycle. Parapyruvate′s potential to inhibit KGDHC paves the way for research in cell biology and biochemistry, covering cell senescence, mitochondrial dysfunction, metabolic regulation, and aging-related diseases.
Anwendung
Parapyruvate can be used
- to study mitochondrial metabolomics
- to study age related disorders (Alzheimer′s and Parkinson′s research)
Biochem./physiol. Wirkung
Parapyruvate is formed via an adol condensation reaction of pyruvate
Leistungsmerkmale und Vorteile
High quality compound suitable for multiple research applications
Sonstige Hinweise
For additional information on our range of Biochemicals, please complete this form.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
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