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63174

Sigma-Aldrich

N-(3-Carboxypropyl)-maleinimid

≥98.0% (T)

Synonym(e):

4-Maleinimido-buttersäure, N-Maleoyl-4-amino-buttersäure

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About This Item

Empirische Formel (Hill-System):
C8H9NO4
CAS-Nummer:
57078-98-5
Molekulargewicht:
183.16
Beilstein:
1455876
MDL-Nummer:
MFCD00043139
UNSPSC-Code:
12352106
PubChem Substanz-ID:
329759801
NACRES:
NA.25

Qualitätsniveau

100

Assay

≥98.0% (T)

mp (Schmelzpunkt)

95-98 °C

SMILES String

OC(=O)CCCN1C(=O)C=CC1=O

InChI

1S/C8H9NO4/c10-6-3-4-7(11)9(6)5-1-2-8(12)13/h3-4H,1-2,5H2,(H,12,13)

InChIKey

NCPQROHLJFARLL-UHFFFAOYSA-N

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Anwendung

Gamma-maleimidobutyric acid may be used as a spacer in the construction of drug and other types of bioconjugates. 4-Maleimidobutyric acid is used with N-hydroxysuccinimide ester as a bifunctional cross-linking agent.
Modification reagent for thiol groups in proteins

Sonstige Hinweise

SH-label for the modification of peptides and proteins; Used for the preparation of a new bleomycin analog for Enzyme Immuno Assay (EIA); probe for membrane SH-groups

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Analysenzertifikate (COA)

Lot/Batch Number
BCBS9292V
BCBR2680V
1431812V
1431812
1348754

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K Fujiwara et al.
Cancer research, 41(10), 4121-4126 (1981-10-01)
An antibody directed toward pepleomycin, a new antitumor antibiotic related structurally to bleomycin, has been produced in rabbits by immunization with a pepleomycin-protein conjugate which was prepared by a novel procedure of coupling pepleomycin to mercaptosuccinylated bovine serum albumin using
Biochemical Society Transactions, 11, 753-753 (1983)
N-polymethylenecarboxymaleimides -- a new class of probes for membrane sulphydryl groups.
D G Griffiths et al.
FEBS letters, 134(2), 261-263 (1981-11-16)
Marie Pribylova et al.
International journal of pharmaceutics, 415(1-2), 175-180 (2011-06-15)
A new targeted conjugates in which paclitaxel was used as a cytostatic compound and an analog of the gonadotropin-releasing hormone (GnRH) as a targeting moiety were synthesized. The molecule of the peptide hormone GnRH was modified to allow its connection
Weibo Cai et al.
Nature protocols, 3(1), 89-96 (2008-01-15)
To take full advantage of the unique optical properties of quantum dots (QDs) and expedite future near-infrared fluorescence (NIRF) imaging applications, QDs need to be effectively, specifically and reliably directed to a specific organ or disease site after systemic administration.
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