22632

Chinin -hydrochlorid Dihydrat

tested according to Ph. Eur.

• Synonym(e): Chinini hydrochloridum, (8α, 9R)-6′-Methoxycinchonan-9-ol -monohydrochlorid Dihydrat
• Empirische Formel (Hill-System): C₂₀H₂₄N₂O₂ · HCl · 2H₂O
• CAS-Nummer: 6119-47-7
• Molekulargewicht: 396.91
• Beilstein: 6112655
• EG-Nummer: 205-001-1
• MDL-Nummer: MFCD00151248
• UNSPSC-Code: 12352210
• PubChem Substanz-ID: 329752329
• NACRES: NA.25

Eigenschaften

• Agentur: USP/NF; tested according to Ph. Eur.
• Qualitätsniveau: 100
• Form: solid
• Löslichkeit: water: soluble 0.25 mg in 5 ml
• Anwendung(en): pharmaceutical (small molecule)
• SMILES String: O.O.Cl.COc1ccc2nccc([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1
• InChI: 1S/C20H24N2O2.ClH.2H2O/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;;;/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;1H;2*1H2/t13-,14-,19-,20+;;;/m0.../s1
• InChIKey: MPQKYZPYCSTMEI-FLZPLBAKSA-N

Beschreibung

Anwendung

Quinine hydrochloride dehydrate has been used for fluorescent in situ detection of quinine in cinchona bark using UV resonance raman spectroscopy. It has also been used as a actinometric system to measure the light-induced changes in ruthenium anticancer agent, NAMI-A.

Biochem./physiol. Wirkung

Quinine is a very effective anti-malarial treatment but is considered toxic for routine treatment due to the development of drug resistance in the malarial parasites. It acts as blood schizonticide.Quinine reportedly blocks the membrane conductance of potassium in enteric neurons.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Danger
• H-Sätze: H302,H317,H334
• P-Sätze: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Gefahreneinstufungen: Acute Tox. 4 Oral - Resp. Sens. 1 - Skin Sens. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves