11332

Atropin -sulfat (Salz) Monohydrat

tested according to Ph. Eur.

• Synonym(e): Atropini sulfas, α-(Hydroxymethyl)-phenylessigsäure-8-methyl-8-azabicyclo[3.2.1]oct-3-ylester, (±)-Tropintropat
• Lineare Formel: (C₁₇H₂₃NO₃)₂ · H₂SO₄ · H₂O
• CAS-Nummer: 5908-99-6
• Molekulargewicht: 694.83
• Beilstein: 6109275
• EG-Nummer: 200-235-0
• MDL-Nummer: MFCD00074815
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329749385
• NACRES: NA.21

Eigenschaften

• Agentur: USP/NF; tested according to Ph. Eur.
• Qualitätsniveau: 200
• mp (Schmelzpunkt): 189-192 °C (A) (lit.)
• Löslichkeit: water: soluble 2500 g/L at 4 °C
• Anwendung(en): pharmaceutical (small molecule)
• SMILES String: O.OS(O)(=O)=O.CN1[C@H]2CC[C@@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3.CN4[C@H]5CC[C@@H]4C[C@@H](C5)OC(=O)C(CO)c6ccccc6
• InChI: 1S/2C17H23NO3.H2O4S.H2O/c2*1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12;1-5(2,3)4;/h2*2-6,13-16,19H,7-11H2,1H3;(H2,1,2,3,4);1H2/t2*13-,14+,15+,16?;;
• InChIKey: JPKKQJKQTPNWTR-CHYDPLAESA-N
• Angaben zum Gen: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131)

Beschreibung

Anwendung

Atropine sulfate salt monohydrate has been used for anaesthetizing mice for intranasal administration of ropinirole or 7-OH-DPAT.

Biochem./physiol. Wirkung

Atropine sulfate salt monohydrate is a competitive nonselective antagonist of central and peripheral muscarinic acetylcholine receptors. Atropine is a cholinergic receptor antagonist isolated from Atropa belladona L., Datura stramonium L. and other plants of the solanaceae family. It blocks the ion currents mediated by neuronal nicotinic acetylcholine receptors. Further, it blocks the acetylcholine (ACh)-induced relaxations in human pulmonary veins.

Kompetitiver nichtselektiver Antagonist an zentralen und peripheren muskarinischen Acetylcholinrezeptoren.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H300 + H330
• P-Sätze: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Gefahreneinstufungen: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges