MABT908

Anti-Integrin beta-8 Antibody, clone 6B9

clone 6B9, from mouse

• Synonym(e): ITGB8
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 6B9, monoclonal
• Speziesreaktivität: human
• Methode(n): immunohistochemistry: suitable (paraffin)
• Isotyp: IgG1κ
• NCBI-Hinterlegungsnummer: NP_002205
• UniProt-Hinterlegungsnummer: P26012
• Versandbedingung: ambient
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... ITGB8(3696)

Beschreibung

Allgemeine Beschreibung

Integrin beta-8 (UniProt: P26012) is encoded by the ITGB8 gene (Gene ID: 3696) in human. Integrin complexes mediate cell-cell and cell-extracellular matrix interactions and this complex plays a role in human airway epithelial proliferation. The integrin receptors are composed of alpha and beta subunits and each subunit crosses the membrane once, with most of the polypeptide residing in the extracellular space, and has two short cytoplasmic domains. Integrin beta-8 is a single-pass type I membrane protein that associates with alpha V chain in a non-covalent manner to make a heterodimer that serves as a receptor for vitronectin, fibrin, and the latency associated peptide (LAP). Integrin beta-8 binding to LAP is reported to promote the proteolytic release of active TGF-beta from LAP. Integrin beta-8 contains a VWFA domain and four cysteine-rich repeats. It is required for vascular morphogenesis in the embryonic brain and yolk sac. Higher expression of integrin beta-8 is observed in placenta, kidney, brain, ovary, uterus, and in several transformed cells. It is transiently expressed in 293 human embryonic kidney cells. Higher expression of ITGB8 is linked to high angiogenic and poorly invasive glioblastoma tumors. Conversely, low expression of ITGB8 correlates with highly invasive, but low angiogenic tumors. Higher expression of integrin beta-8 is observed in placenta, kidney, brain, ovary, uterus, and in several transformed cells. It is transiently expressed in 293 human embryonic kidney cells.

Spezifität

Clone 6B9 detects human integrin beta-8 subunit.

Immunogen

A truncated recombinant form of human Integrin B8 corresponding to first 682 amino acids.

Anwendung

Research Category
Zellstruktur

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Integrin beta-8 in human colon and human placenta tissues.

This mouse monoclonal Anti-Integrin beta-8 Antibody, clone 6B9, Cat. No. MABT908, is tested for use in Immunohistochemistry (Paraffin) for the detection of Integrin beta-8.

Qualität

Evaluated by Immunohistochemistry in human colon tissue.

Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected Integrin beta-8 in human colon tissue.

Zielbeschreibung

85.63 kDa calculated.

Physikalische Form

Protein G purified

Format: Purified

Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Sonstige Hinweise

Concentration: Please refer to lot specific datasheet.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1