MABT39

Anti-Laminin alpha 5 Antibody, clone 4B12

clone 4B12, from mouse

• Synonym(e): laminin, alpha 5, Laminin-15 subunit alpha, laminin alpha-5 chain, Laminin-11 subunit alpha, laminin subunit alpha-5, Laminin-10 subunit alpha, Laminin α5, Lamininα5, Laminin-α5
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: 4B12, monoclonal
• Speziesreaktivität: human
• Methode(n): immunohistochemistry: suitable
• Isotyp: IgG1λ
• NCBI-Hinterlegungsnummer: NP_005551
• UniProt-Hinterlegungsnummer: O15230
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... LAMA5(3911)

Beschreibung

Allgemeine Beschreibung

Laminin alpha 5 (α5) is a member of the laminin family of extracellular matrix glycoproteins. Laminin’s are important in cell migration, differentiation and in tumor cell incursion. Research shows that laminin alpha 5 may be an early marker of sexual differentiation. In rat, the laminin alpha 5 chain seems to halt expression in the basement membrane of Sertoli cells when secretion of AMH begins but expression increases two weeks after birth when AMH secretion stops. Laminin alpha 5 shows up early during lung development in mice. It has also been linked to inflammatory cell chemotaxis and metalloproteinase activity and may play a role in creating and sustaining mucosal patterns of the mouse small intestine.

Immunogen

Laminin purified from human placenta

Anwendung

Research Category
Zellstruktur

Research Sub Category
ECM-Proteine

Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected Laminin alpha 5 in human blood vessels and metastatic colorectal adenocarcinoma tissues.

This Anti-Laminin alpha 5 Antibody, clone 4B12 is validated for use in IH for the detection of Laminin alpha 5.

Qualität

Evaluated by Immunohistochemistry in human precancerous colorectal lesion tissue.

Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected Laminin alpha 5 in human precancerous colorectal lesion tissue.

Zielbeschreibung

400 kDa calculated

Physikalische Form

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1λ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Hinweis zur Analyse

Control
Human precancerous colorectal lesion tissue

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable