MABN774

Anti-TDP-43 Antibody, clone DB9

clone DB9, from mouse

• Synonym(e): TAR DNA-binding protein 43, TDP-43, TDP43, TAR DNA binding protein-43
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: DB9, monoclonal
• Speziesreaktivität: human
• Methode(n): immunohistochemistry: suitable; western blot: suitable
• Isotyp: IgG1κ
• NCBI-Hinterlegungsnummer: NP_031401
• UniProt-Hinterlegungsnummer: Q13148
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... TARDBP(23435)

Beschreibung

Allgemeine Beschreibung

TAR DNA-binding protein 43 (TDP-43) belongs to the hnRNP protein family and plays an important role in transcription, pre-mRNA splicing, mRNA stability and mRNA transport. It is involved in splicing of the apolipoprotein A-II and cystic fibrosis transmembrane gene. This protein is highly expressed in the pancreas, placenta, lung, genital tract and spleen. Mutations in TDP-43 have been associated with amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson′s disease and Alzheimer′s disease.

Immunogen

The antibody was raised against an immunogen consisting of His-tagged recombinant protein corresponding to amino acid residues 208-414 of human TDP-43.

Anwendung

Detect TDP-43 using this Anti-TDP-43 Antibody, clone DB9 validated for use in western blotting & IHC.

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TDP-43 in human cerebellum, pancreas, and thalamus tissues.

Qualität

Evaluated by Western Blotting in SH-SY-5Y cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected TDP-43 in 10 µg of SH-SY-5Y cell lysate.

Zielbeschreibung

~43 kDa observed

Physikalische Form

Format: Purified

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable