MABN449

Anti-Protein capicua homolog (CIC), clone 6E12.1 Antibody

clone 6E12.1, 1 mg/mL, from mouse

• Synonym(e): Protein capicua homolog, Protein capicua homolog (CIC)
• UNSPSC-Code: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: mouse
• Qualitätsniveau: 100
• Antikörperform: purified immunoglobulin
• Antikörper-Produkttyp: primary antibodies
• Klon: 6E12.1, monoclonal
• Speziesreaktivität: human, rat
• Konzentration: 1 mg/mL
• Methode(n): immunohistochemistry: suitable (paraffin)
• Isotyp: IgG1κ
• NCBI-Hinterlegungsnummer: NP_055940
• UniProt-Hinterlegungsnummer: Q96RK0
• Versandbedingung: wet ice
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... CIC(23152)

Beschreibung

Allgemeine Beschreibung

Protein capicua homolog (CIC) , also known as Capicua Transcriptional Repressor, Capicua Homolog, and encoded by the gene CIC, is a transcriptional repressor which plays a role in development of the central nervous system (CNS). CIC is a new subfamily of the HMG-box superfamily and the gene′s expression is predominantly restricted to immature granule cells in the cerebellum, hippocampus and olfactory bulb in the CNS, and thus the gene is implicated in CNS development, in particular in granule cell development. CIC appears to be central to cerebellar development and ErbB signaling as well. Recent research has demonstrated that CIC is highly expressed in certain cancers including medulloblastomas, but also the loss of expression may serve as a biomarker for other cancer types such as oligodendrogliomas.

Immunogen

GST-tagged recombinant protein corresponding to human Protein capicua homolog (CIC).

Anwendung

Research Category
Neurowissenschaft

Research Sub Category
Entwicklungsabhängige Signalübertragung

Immunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected Protein capicua homolog (CIC) in human cerebral cortex, rat olfactory bulb, and rat cerebral cortex tissue.

This Anti-Protein capicua homolog (CIC), clone 6E12.1 Antibody is validated for use in Immunohistochemistry (Paraffin) for the detection of Protein capicua homolog (CIC).

Qualität

Evaluated by Immunohistochemistry in rat cerebellum tissue.

Immunohistochemistry Analysis: A 1:500 dilution of this antibody detected Protein capicua homolog (CIC) in rat cerebellum tissue.

Zielbeschreibung

164 kDa calculated

Physikalische Form

Protein G Purified

Format: Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Lagerung und Haltbarkeit

Stable for 1 year at 2-8°C from date of receipt.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable