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MAB2052

Sigma-Aldrich

Anti-Disialoganglioside GD2 Antibody, clone 14G2a

clone 14.2Ga, Chemicon®, from mouse

Synonym(e):

Anti-GD2 Antibody, Clone 14G2a Anti-GD2, GD2 Detection Antibody

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About This Item

UNSPSC-Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Biologische Quelle

mouse

Qualitätsniveau

100

Antikörperform

affinity purified immunoglobulin

Antikörper-Produkttyp

primary antibodies

Klon

14.2Ga, monoclonal

Speziesreaktivität

human

Hersteller/Markenname

Chemicon®

Methode(n)

flow cytometry: suitable
immunofluorescence: suitable
immunohistochemistry: suitable

Isotyp

IgG2a

Versandbedingung

wet ice

Posttranslationale Modifikation Target

unmodified

Spezifität

Reacts specifically with human GD2 ganglioside.

Anwendung

Anti-Disialoganglioside GD2 Antibody, clone 14G2a detects level of Disialoganglioside GD2 & has been published & validated for use in FC, IF, IH.
Immunohistochemistry (frozen tissue sections)(Cheresh et al., 1986)

Immunofluorescence of cells in culture

Flow cytometry: 1-2 μg per 10E6 cells

Cytotoxicity for GD2 positive cells (Mujoo et al., 1987, 1989)

Optimal working dilutions must be determined by end user.

Physikalische Form

Cell culture supernatant in 0.02M PB, pH 7.6, 0.25M NaCl containing 0.1% Sodium Azide
Format: Purified

Sonstige Hinweise

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Functional properties and effect on growth suppression of human neuroblastoma tumors by isotype switch variants of monoclonal antiganglioside GD2 antibody 14.18.
Mujoo, K, et al.
Cancer Research, 49, 2857-2861 (1989)
Biosynthesis and expression of the disialoganglioside GD2, a relevant target antigen on small cell lung carcinoma for monoclonal antibody-mediated cytolysis.
Cheresh, D A, et al.
Cancer Research, 46, 5112-5118 (1986)
Patrizia Garbati et al.
Biomedicines, 8(11) (2020-11-07)
To overcome the lack of effective pharmacological treatments for high-risk neuroblastoma (HR-NB), the development of novel in vitro and in vivo models that better recapitulate the disease is required. Here, we used an in vitro multiclonal cell model encompassing NB
Hideki Yoshida et al.
Scientific reports, 10(1), 1199-1199 (2020-01-29)
β-1,4-N-Acetyl-Galactosaminyltransferase 1 (B4GALNT1) encodes the key enzyme B4GALNT1 to generate gangliosides GM2/GD2. GM2/GD2 gangliosides are surface glycolipids mainly found on brain neurons as well as peripheral nerves and skin melanocytes and are reported to exacerbate the malignant potential of melanomas.
Isolation of retinal progenitor cells from post-mortem human tissue and comparison with autologous brain progenitors.
Henry Klassen, Boback Ziaeian, Ivan I Kirov, Michael J Young, Philip H Schwartz
Journal of Neuroscience Research null

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