HSCRMAG32KPX14

MILLIPLEX^® Human Soluble Cytokine Receptor Panel, HSCRMAG-32K- Immunology Multiplex Assay

Simultaneously analyze multiple cytokine and chemokine biomarkers with Bead-Based Multiplex Assays using the Luminex technology, in human serum, plasma and cell culture samples.

• Synonym(e): Human Cytokine Receptor Multiplex Kit, Luminex^® Human Cytokine Receptor Immunoassay, Millipore Cytokine Receptor Panel
• UNSPSC-Code: 12161503
• eCl@ss: 32161000
• NACRES: NA.47

Eigenschaften

• Qualitätsniveau: 200
• Speziesreaktivität: human
• Hersteller/Markenname: Milliplex^®
• assay range: accuracy: 91-104%; sensitivity: 4-208 pg/mL; (Overnight Incubation minDC); standard curve range: 12.2-50,000 pg/mL; (sIL-4R, sIL-6R, sRAGE, sTNFRI, sTNFRII); standard curve range: 122.1-500,000 pg/mL; (sEGFR, sIL-1RII, sVEGF-R1, sVEGF-R2, sVEGF-R3); standard curve range: 24.4-100,000 pg/mL; (sCD30, sgp130, sIL-1RI, sIL-2Rα); inter-assay cv: <15%; intra-assay cv: <10%
• Methode(n): multiplexing: suitable
• Kompatibilität: configured for Premixed
• Nachweisverfahren: fluorometric (Luminex xMAP)
• Versandbedingung: wet ice

Beschreibung

Allgemeine Beschreibung

Cytokine receptors constitute an integral part of cytokine biology. Like cytokines, cytokine receptors are involved in normal physiological and pathological processes of almost all disease states. Soluble cytokine receptors naturally arise from genes encoding membrane- bound receptors or are direct derivatives of the receptors themselves. The discovery that soluble cytokine receptors are involved in regulating excessive inflammatory responses and modulating immune events has stimulated significant research interest in their potential role as immunotherapeutic agents. Many of these soluble cytokine receptors can inhibit the binding and biological activity of their cytokine ligands, making them very specific cytokine antagonists.

MILLIPLEX^® Human Soluble Cytokine Receptor Panel is to be used for the simultaneous quantification of 14 soluble cytokine receptors in human serum, plasma and cell / tissue culture supernatant samples. This kit uses a 96-well format, contains a lyophilized standard cocktail, two internal assay quality controls and can measure up to 38 samples in duplicate.

The Luminex^® xMAP^® platform uses a magnetic bead immunoassay format for ideal speed and sensitivity to quantitate multiple analytes simultaneously, dramatically improving productivity while conserving valuable sample volume.

Panel Type: Cytokines/Chemokines

Spezifität

Cross Reactivty
There is no detectable cross-reactivity within the panel.

Anwendung

• Analytes: sCD30, sEGFR, sGP130, sIL-1RI, sIL-1RII, sIL-2Rα, sIL-4R, sIL-6R, sRAGE, sTNFRI, sTNFRII, sVEGFR1, sVEGFR2, sVEGFR3
• Recommended Sample type: Serum, plasma or tissue/cell lysate and culture supernatant
• Recommended Sample dilution: 1:5 dilution for plasma or serum or neat cell culture supernatant
• Assay Run Time: Overnight
• Research Category: Inflammation & Immunology

Lagerung und Haltbarkeit

Recommended storage for kit components is 2 - 8°C.

Sonstige Hinweise

Please contact Technical Service for linearity of dilution.

Sensitivity: Please see kit protocol for individual assay sensitivities.

Rechtliche Hinweise

Luminex is a registered trademark of Luminex Corp

MILLIPLEX is a registered trademark of Merck KGaA, Darmstadt, Germany

xMAP is a registered trademark of Luminex Corp

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Piktogramme: GHS08,GHS05,GHS07,GHS09
• Signalwort: Danger
• H-Sätze: H302 + H312 + H332,H317,H318,H373,H411
• P-Sätze: P273 - P280 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P314
• Gefahreneinstufungen: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1 - STOT RE 2
• Zielorgane: Respiratory Tract
• Lagerklassenschlüssel: 10 - Combustible liquids