869001-M

Follikelstimulierendes Hormon, menschliche Hypophyse, Iodierungsqualität

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, CAS 9002-68-0, is a native pituitary protein that regulates Sertoli cells by acting on G-protein-linked cell surface FSH receptors.

• Synonym(e): Follikelstimulierendes Hormon, menschliche Hypophyse, Iodierungsqualität, hFSH
• CAS-Nummer: 9002-68-0
• MDL-Nummer: MFCD00131099
• UNSPSC-Code: 12352202
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human pituitary glands
• Qualitätsniveau: 200
• Sterilität: non-sterile
• Produktlinie: Calbiochem^®
• Assay: ≥90%
• Form: lyophilized solid
• Spezifische Aktivität: ≥2000 IU/mg
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze
• Verunreinigungen: ≤0.1% hCG; ≤0.5% hLH, hTSH
• pI: 4.1
• Löslichkeit: PBS: soluble
• Lagertemp.: −20°C

Beschreibung

Allgemeine Beschreibung

Follicle-stimulating hormone (FSH) belongs to the family of glycoprotein hormones. It is synthesized in the gonadotrophs present in the pituitary gland. FSH contains non-covalently associated α- and β-subunits and is a disulfide-rich heterodimer.

Research area: Cell Signaling

Biochem./physiol. Wirkung

Follicle-stimulating hormone (FSH) participates in the regulation of reproduction in mammals. It exerts its effects through a G-protein-coupled receptor known as follicle-stimulating hormone receptor (FSHR) that is located on the granulosa cells of the ovaries and Sertoli cells of the testes. FSH plays a role in the maturation of ovarian follicles in females and supports spermatogenesis by activating Sertoli cell proliferation in males. The interaction of FSH with its receptor FSH-R leads to the activation of G-protein coupled receptors/cyclic adenosine monophosphate (cAMP)/protein kinase A pathways to transmit intracellular signals.

Warnhinweis

Toxizität: Karzinogen/Teratogen (D)

Angaben zur Herstellung

Aus Gewebe von Personen hergestellt, die in zertifizierten Tests für HBsAg und Antikörper gegen HIV und HCV als negativ befunden wurden.

Rekonstituierung

Nach der Rekonstitution in Aliquote aufteilen und einfrieren (-20 °C). Stammlösungen sind bei -20 °C bis zu 6 Monate haltbar.

Sonstige Hinweise

Costrici, N., et al. 1995. Endocrinology136, 4705.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable