8.51095

PyOxim

Novabiochem^®

• Synonym(e): 1-Cyano-2-ethoxy-2-oxoethylideneaminooxy-tris-pyrrolidino-phosphonium hexafluorophosphate
• Empirische Formel (Hill-System): C₁₇H₂₉F₆N₅O₃P₂
• CAS-Nummer: 153433-21-7
• Molekulargewicht: 527.38
• MDL-Nummer: MFCD18643381
• UNSPSC-Code: 12352126

Eigenschaften

• Qualitätsniveau: 300
• Produktlinie: Novabiochem^®
• Assay: ≥99.0% (HPLC)
• Form: powder
• Eignung der Reaktion: reaction type: Coupling Reactions
• Hersteller/Markenname: Novabiochem^®
• Anwendung(en): peptide synthesis
• Lagertemp.: 15-25°C
• InChI: 1S/C17H29N5O3P.F6P/c1-2-24-17(23)16(15-18)19-25-26(20-9-3-4-10-20,21-11-5-6-12-21)22-13-7-8-14-22;1-7(2,3,4,5)6/h2-14H2,1H3;/q+1;-1/b19-16+;
• InChIKey: RDWDVLFMPFUBDV-PXMDEAMVSA-N

Beschreibung

Allgemeine Beschreibung

PyOxim ^[1] is a novel reagent which mediates coupling reactions with efficiencies superior to HATU and PyBOP and comparable to COMU. It is has excellent solubility in DMF and is stable in solution under an inert atmosphere for two days. Unlike HATU and HBTU, it cannot cause chain terminating side reactions and is, therefore, ideal for the synthesis of cyclic peptides. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents.


Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] R. Subiros-Funosas, et al. (2010) Org. Biomol. Chem., 8, 3665.

Leistungsmerkmale und Vorteile

• Mediates coupling with superior efficiency to PyBOP, TBTU, and HCTU
• Mediates coupling with low racemization or epimerization
• Ideal for fragment condensation and synthesis of cyclic peptides as the reagent cannot cause guanidinylation
• Excellent solubility in DMF and NMP

Hinweis zur Analyse

Farbe (visuell): weiß bis beigestichig
Aussehen der Substanz (visuell): Pulver
Identität (IR): entspricht
Gehalt (HPLC, Fl.%): ≥ 99.0 %
Löslichkeit (1 mmol in 2 ml DMF): klar löslich

Rechtliche Hinweise

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable