8.14815

Sodium chlorite

(25% solution in water) for synthesis

• Synonym(e): Chlorous acid, sodium salt
• UNSPSC-Code: 12352302
• NACRES: NA.22

Eigenschaften

• Dampfdruck: 20 hPa ( 20 °C)
• Qualitätsniveau: 200
• Form: liquid
• Wirksamkeit: 1136 mg/kg LD₅₀, oral (Rat)
• pH-Wert: 12-13 (20 °C in H₂O)
• bp: ≥100 °C/1013 hPa
• mp (Schmelzpunkt): <-3 °C
• Dichte: 1.20-1.25 g/cm³ at 20 °C
• Lagertemp.: 2-30°C

Beschreibung

Anwendung

Sodium chlorite (NaClO₂) can be used as an oxidizing agent for the conversion of:

• Aldehydes to corresponding carboxylic acids under mild reaction conditions in the presence of scavengers such as sulfamic acid or resorcinol.
• Primary alcohols to carboxylic acids in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and NaOCl.
• Aliphatic and aromatic thiols to the corresponding disulfides.
• Aryl boronic acids to phenols via ipso-hydroxylation.
• Cyclic benzylic ethers and N-protected cyclic benzylic amines to benzolactones and benzolactams.
• Alkenes to epoxides using aldehydes as promoters.
• Alkenes and cycloalkenes to 1, 2 diols via osmium-catalyzed Sharpless asymmetric dihydroxylation.

It can also be used in combination with Br₂ to synthesize 2-carboxyazetidin-2-ones from furanylazetidinones.

Hinweis zur Analyse

Gehalt (iodometrisch): 23.0 - 26.0 %
Dichte (d 20 °C/ 4 °C): 1.200 - 1.220

Sicherheitshinweise

• Piktogramme: GHS05,GHS06,GHS08,GHS09
• Signalwort: Danger
• H-Sätze: H290 - H302 - H311 - H314 - H373 - H400
• P-Sätze: P273 - P280 - P301 + P312 - P303 + P361 + P353 - P305 + P351 + P338 - P314
• Gefahreneinstufungen: Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1 - STOT RE 2
• Zielorgane: spleen
• Zusätzliche Gefahrenhinweise: EUH032
• Lagerklassenschlüssel: 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable