5.08225

(Z)-4-Hydroxytamoxifen

≥99% (HPLC), liquid, estrogen receptor modulator, Calbiochem

• Synonym(e): InSolution Tamoxifen, 4-Hydroxy-, ( Z)-, ( Z)-4-(1-(4-(Dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl)phenol, ( Z)-4-(1-(4-(2-(Dimethylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol, (Z)-4-Hydroxytamoxifen, (Z)-4-OH-TAM, trans-4-Hydroxytamoxifen
• Empirische Formel (Hill-System): C₂₆H₂₉NO₂
• CAS-Nummer: 68047-06-3
• Molekulargewicht: 387.51
• MDL-Nummer: MFCD00278780
• UNSPSC-Code: 51111800
• NACRES: NA.77

Eigenschaften

• product name: (Z)-4-Hydroxytamoxifen, InSolution, ≥99%
• Qualitätsniveau: 100
• Assay: ≥99% (HPLC)
• Form: liquid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Lagertemp.: −70°C
• InChI: 1S/C26H29NO2/c1-4-25(20-10-14-23(28)15-11-20)26(21-8-6-5-7-9-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
• InChIKey: DODQJNMQWMSYGS-QPLCGJKRSA-N

Beschreibung

Allgemeine Beschreibung

A 10 mM (2 mg/516 µL) sterile-filtered solution of (Z)-4-Hydroxytamoxifen in ethanol.

A cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
Estrogen receptor

Warnhinweis

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Physikalische Form

A 10 mM (2 mg/516 µL) sterile-filtered solution of (Z)-4-Hydroxytamoxifen (Cat. No. 579002) in EtOH.

Rekonstituierung

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C. Use only anhydrous, 200 proof ethanol for further dilutions.

Sonstige Hinweise

Gundimeda, U., et al. 1996. J. Biol. Chem.271, 13504.
Ye, Q. and Bodell, W.J. 1996. Carcinogenesis17, 1747.
Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol.21, 985.
Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health4, 364.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS02,GHS07,GHS08
• Signalwort: Danger
• H-Sätze: H225 - H319 - H350 - H360FD - H412
• P-Sätze: P202 - P210 - P233 - P273 - P305 + P351 + P338 - P308 + P313
• Gefahreneinstufungen: Aquatic Chronic 3 - Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - Repr. 1B
• Lagerklassenschlüssel: 3 - Flammable liquids
• WGK: WGK 3
• Flammpunkt (°F): 55.4 °F
• Flammpunkt (°C): 13 °C