5.06416

Beclin-1 Activator II, retro-inverso TAT-Beclin-1

• Synonym(e): Beclin-1 Activator II, retro-inverso TAT-Beclin-1, (D)-H₂N-RRRQRRKKRGY-GG-TGFEGDHWIEFTANFVNT-CO₂H, Atg6 Activator II, Beclin-1-GAPR-1 Interaction Blocker II, Vps30 Activator II
• Empirische Formel (Hill-System): C₁₆₄H₂₅₁N₅₇O₄₅
• Molekulargewicht: 3741.10
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥95% (HPLC)
• Qualitätsniveau: 100
• Form: powder
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated (hygroscopic); protect from light
• Farbe: white
• Löslichkeit: DMSO: 50 mg/mL; water: 50 mg/mL
• Lagertemp.: 2-8°C

Beschreibung

Allgemeine Beschreibung

Tat-beclin 1, a peptide, is derived from a segment of the autophagy protein beclin 1, which binds to human immunodeficiency virus (HIV)-1 Nef. It serves as a potent inducer of autophagy. It interacts with GAPR-1 (GLIPR2), a recently identified negative regulator of autophagy. Tat-beclin 1 has been found to reduce the accumulation of polyglutamine expansion protein aggregates and the replication of various pathogens (including HIV-1) in vitro. Moreover, it has demonstrated the ability to decrease mortality in mice infected with chikungunya or West Nile virus.

Biochem./physiol. Wirkung

Cell permeable: yes

Primary Target
GAPR-1/GLIPR2

Reversible: yes

Verpackung

Packaged under inert gas

Warnhinweis

Toxicity: Standard Handling (A)

Sequenz

(D)-H-arg-arg-arg-gln-arg-arg-lys-lys-arg-Gly-tyr~Gly-Gly~thr-Gly-phe-glu-Gly-asp-his-trp-ile-glu-phe-thr-ala-asn-phe-val-asn-thr-OH

Physikalische Form

Supplied as a trifluoroacetate salt.

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Sonstige Hinweise

Shoji-Kawata, S., et al. 2013. Nature.494, 201.

Rechtliche Hinweise

Sold under license of US Patent 8,722,628.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable