230950

Ciglitazone

A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective PPARγ agonist (EC₅₀ = 3 µM).

• Synonym(e): Ciglitazone, (±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]thiazolidine-2,4-dione, PPAR Agonist II, PPARγ Agonist I
• Empirische Formel (Hill-System): C₁₈H₂₃NO₃S
• CAS-Nummer: 74772-77-3
• Molekulargewicht: 333.45
• MDL-Nummer: MFCD00865499
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze
• Farbe: tan
• Löslichkeit: DMSO: ≥25 mg/mL; ethanol: ≥25 mg/mL
• Versandbedingung: ambient
• Lagertemp.: 2-8°C
• InChI: 1S/C18H23NO3S/c1-18(9-3-2-4-10-18)12-22-14-7-5-13(6-8-14)11-15-16(20)19-17(21)23-15/h5-8,15H,2-4,9-12H2,1H3,(H,19,20,21)
• InChIKey: YZFWTZACSRHJQD-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective PPARγ agonist (EC₅₀ = 3 µM).

A potent thiazolinedione (TDZ) type anti-hyperglycemic agent and a selective peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC₅₀ = 3 µM).

Biochem./physiol. Wirkung

Cell permeable: no

EC50 = 3 µM as PPARγ agonist

Primary Target
Selective PPARγ agonist

Product does not compete with ATP.

Reversible: no

Warnhinweis

Toxicity: Harmful (C)

Rekonstituierung

Stock solutions are stable for up to 3 months at -20°C.

Sonstige Hinweise

Jha, R.J. 1999. Clin. Exp. Hypertens. 21, 157.
Xin, X., et al. 1999. J. Biol. Chem. 274, 9116.
Lohrke, B., et al. 1998. J. Endocrinol. 159, 429.
Willson, T.M., et al. 1996. J. Med. Chem. 39, 665.
Cantello, B.C., et al. 1994. J. Med. Chem. 37, 3977.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable