05-23-2401

Calcitonin, Salmon

Calcitonin, Salmon, CAS 47931-85-1, is a 32 amino acid synthetic calcitonin that is shown to stimulate bone formation and inhibit bone resorption. Has ability to cross mucous membranes.

• Synonym(e): Calcitonin, Salmon
• Empirische Formel (Hill-System): C₁₄₅H₂₄₀N₄₄O₄₈S₂
• CAS-Nummer: 47931-85-1
• Molekulargewicht: 3431.85
• MDL-Nummer: MFCD00133859
• UNSPSC-Code: 12352202
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Sterilität: non-sterile
• Assay: ≥98% (HPLC)
• Form: lyophilized
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; desiccated (hygroscopic)
• Löslichkeit: 5% acetic acid: 1 mg/mL
• Versandbedingung: ambient
• Lagertemp.: −20°C
• InChI: 1S/C145H240N44O48S2/c1-65(2)45-86(175-139(232)110(70(11)12)183-136(229)99-63-239-238-62-79(148)117(210)178-96(59-191)134(227)174-92(52-104(151)202)131(224)172-90(49-69(9)10)129(222)180-98(61-193)135(228)187-114(74(16)197)142(235)181-99)118(211)158-55-106(204)162-80(25-18-20-40-146)120(213)169-89(48-68(7)8)128(221)179-97(60-192)133(226)167-83(34-37-102(149)200)122(215)165-85(36-39-109(207)208)123(216)171-88(47-67(5)6)127(220)173-91(51-77-54-156-64-161-77)130(223)164-81(26-19-21-41-147)121(214)170-87(46-66(3)4)126(219)166-84(35-38-103(150)201)125(218)186-113(73(15)196)141(234)177-94(50-76-30-32-78(199)33-31-76)143(236)189-44-24-29-101(189)137(230)168-82(27-22-42-157-145(154)155)124(217)185-112(72(14)195)140(233)176-93(53-105(152)203)132(225)184-111(71(13)194)138(231)160-56-107(205)163-95(58-190)119(212)159-57-108(206)182-115(75(17)198)144(237)188-43-23-28-100(188)116(153)209/h30-33,54,64-75,79-101,110-115,190-199H,18-29,34-53,55-63,146-148H2,1-17H3,(H2,149,200)(H2,150,201)(H2,151,202)(H2,152,203)(H2,153,209)(H,156,161)(H,158,211)(H,159,212)(H,160,231)(H,162,204)(H,163,205)(H,164,223)(H,165,215)(H,166,219)(H,167,226)(H,168,230)(H,169,213)(H,170,214)(H,171,216)(H,172,224)(H,173,220)(H,174,227)(H,175,232)(H,176,233)(H,177,234)(H,178,210)(H,179,221)(H,180,222)(H,181,235)(H,182,206)(H,183,229)(H,184,225)(H,185,217)(H,186,218)(H,187,228)(H,207,208)(H4,154,155,157)
• InChIKey: BBBFJLBPOGFECG-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Synthetic, salmon calcitonin. A 32 amino acid residue peptide that is shown to stimulate bone formation and inhibit bone resorption. Has ability to cross mucous membranes. Has no significant effect on inositol phosphate accumulation.

Synthetic, salmon calcitonin. Calcitonin is a single-chain peptide hormone of 32 amino acid residues with a disulfide bridge between cysteines 1 and 7. It is produced in the parafollicular C cells of the thyroid gland and acts to stimulate bone formation by osteoblasts and inhibits bone resorption. Part of the effect of calcitonin appears to be mediated through increasing cAMP concentrations in osteoclasts. Has ability to cross mucus membranes. Has no significant effect on inositol phosphate accumulation.

Verpackung

Yes

Warnhinweis

Toxicity: Standard Handling (A)

Sequenz

H-Cys¹-Ser-Asn-Leu-Ser-Thr-Cys⁷-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH₂(disulfide bond: 1 → 7)

Physikalische Form

Sold on the basis of peptide content.

Rekonstituierung

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Sonstige Hinweise

Gennari, C. and Agnusdei, D. 1994. Br. J. Clin. Pract.48, 196.
Reginster, J.Y. 1993. Osteoporos. Int. 3 (Suppl. 2), S3.
MacIntyre, I. et al. 1988. Clin. Orthop.217, 45.
Chambers, T.J., et al. 1985. J. Pathol.145, 297.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P264 - P270 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3