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D-920

Supelco

N-Desmethyltrimipramine maleate solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Synonym(e):

N-Desmethyltrimipramine maleate solution

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About This Item

Empirische Formel (Hill-System):
C19H24N2 · C4H4O4
CAS-Nummer:
67341-71-3
Molekulargewicht:
396.48
EG-Nummer:
200-659-6
UNSPSC-Code:
41116107
NACRES:
NA.24

Qualität

certified reference material

Qualitätsniveau

300

Form

liquid

Leistungsmerkmale

Snap-N-Spike®/Snap-N-Shoot®

Verpackung

ampule of 1 mL

Hersteller/Markenname

Cerilliant®

Konzentration

1.0 mg/mL in methanol (as free base)

Methode(n)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Anwendung(en)

clinical testing

Format

single component solution

Lagertemp.

2-8°C

Allgemeine Beschreibung

N-Desmethyltrimipramine is a primary blood metabolite of trimipramine. Trimipramine is a tricyclic antidepressant prescribed for treatment of depression, insomnia, and chronic pain or as an adjunctive therapy for alcohol or opioid withdrawal. This Certified Snap-N-Spike® Solution is applicable for use in LC/MS or GC/MS applications for pain prescription monitoring, urine drug testing, clinical toxicology, and forensic analysis.

Rechtliche Hinweise

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Zielorgane

Eyes

Lagerklassenschlüssel

3 - Flammable liquids

WGK

WGK 2

Flammpunkt (°F)

49.5 °F - closed cup

Flammpunkt (°C)

9.7 °C - closed cup

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Analysenzertifikate (COA)

Lot/Batch Number

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In vitro metabolism of desmethyltrimipramine to yield hydroxylamino compound.
S Ozkirimli et al.
Acta pharmaceutica Suecica, 23(1), 57-59 (1986-01-01)
C B Eap et al.
Therapeutic drug monitoring, 14(5), 380-385 (1992-10-01)
A two-step high-performance liquid chromatography method is described, using a CN column and an alpha 1-acid glycoprotein column, which allows the measurement of the enantiomers of the hydroxy metabolites of trimipramine in plasma of trimipramine-treated patients. Of the four patients
N Jourdil et al.
Journal of chromatography, 613(1), 59-65 (1993-03-05)
A simple procedure is described that permits the simultaneous determination of trimipramine and its two major metabolites, desmethyl- and hydroxytrimipramine, in human plasma or red blood cells (RBCs) at therapeutic concentrations. The extracted biological fluids are injected into a capillary
A A Gulaid et al.
Journal of chromatography, 566(1), 228-233 (1991-05-03)
Trimipramine is a tricyclic antidepressant drug often assayed by gas chromatographic or gas chromatographic-mass spectrometry techniques. A high-performance liquid chromatographic method with electrochemical detection is described for the assay of trimipramine and its major metabolites, monodesmethyltrimipramine and 2-hydroxytrimipramine, in plasma.
J Degen et al.
Medizinische Klinik (Munich, Germany : 1983), 88(3), 129-133 (1993-03-15)
The pharmacokinetics of the antidepressants amitriptyline oxide and trimipramine and their major metabolites amitriptyline, nor-triptyline and desmethyltrimipramine, were studied in twelve healthy male subjects (aged from 22 to 62 years) and twelve patients (aged from 25 to 73 years) with
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