860488P

Safingol

Avanti Research^™ - A Croda Brand 860488P, powder

• Synonym(e): L-threo-dihydrosphingosine (d18:0) z
• Empirische Formel (Hill-System): C₁₈H₃₉NO₂
• CAS-Nummer: 15639-50-6
• Molekulargewicht: 301.51
• UNSPSC-Code: 12352211
• NACRES: NA.25

Eigenschaften

• Form: powder
• Verpackung: pkg of 1 × 5 mg (860488P-5mg)
• Hersteller/Markenname: Avanti Research^™ - A Croda Brand 860488P
• Lipid-Typ: sphingolipids; bioactive lipids
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• SMILES String: CCCCCCCCCCCCCCC[C@@](O)([H])[C@@]([H])(N)CO
• InChI: 1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3
• InChIKey: OTKJDMGTUTTYMP-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Safingol is a synthetic L-threo-stereoisomer of endogenous (D-erythro-) sphinganine. It acts as an inhibitor of protein kinase C and sphingosine kinase in vitro. Safingol is involved in ceramide generation and induction of apoptosis. It is known to stimulate antitumor activity of cisplatin.

Anwendung

Safingol has been used as a substituent of dihydrosphingosine (dhSph) to increase the cytotoxic response in N-(4-hydroxyphenyl)retinamide (4-HPR)-resistant cells.

Verpackung

5 mL Amber Glass Screw Cap Vial (860488P-5mg)

Rechtliche Hinweise

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable